西南医科大学学报2026，Vol.49Issue(1)：1-6,6.DOI:10.3969/j.issn.2096-3351.2026.01.001
肝硬化失代偿期:临床挑战与未来展望
Clinical Challenges and Future Prospects of Decompensated Liver Cirrhosis
摘要
Abstract
Decompensated cirrhosis represents the terminal stage of chronic liver disease progression,characterized by a series of severe complications including ascites,hepatic encephalopathy,and bleeding from ruptured varices,with a poor clinical prognosis.Despite continuous optimization of clinical management strategies,significant challenges remain in early identification,precise inter-vention for complications,and reversal of liver function.This systematic review examines the epidemiological characteristics,patho-physiological mechanisms,etiology,diagnosis and treatment of complications,clinical challenges,and limitations of current therapies for decompensated cirrhosis.It highlights cutting-edge advances in biomarker development,cell therapy and regenerative medicine,novel drug targets,and other emerging fields,offering new diagnostic and therapeutic perspectives to optimize clinical management for patients with decompensated cirrhosis.关键词
肝硬化失代偿/门静脉高压症/静脉曲张/肝性脑病/再代偿Key words
Decompensated cirrhosis/Portal hypertension/Varices/Hepatic encephalopathy/Recompensation分类
医药卫生引用本文复制引用
LU Lungen,WANG Junjun,YANG Yufei..肝硬化失代偿期:临床挑战与未来展望[J].西南医科大学学报,2026,49(1):1-6,6.基金项目
国家自然科学基金(82170620) （82170620）
