国际眼科杂志2026，Vol.26Issue(1)：50-55,6.DOI:10.3980/j.issn.1672-5123.2026.1.09
年龄相关性黄斑变性中的昼夜节律与其他影响因素的交互作用分析
Analysis of the interaction between circadian rhythm and other influencing factors in age-related macular degeneration
摘要
Abstract
Circadian rhythm(CR)is an intrinsic biological clock mechanism within organisms that regulates physiological and biochemical processes,enabling synchronization with periodic fluctuations in the external environment.This rhythmicity not only influences the sleep-wake cycle but also encompasses various physiological functions,including metabolism,hormone secretion,cell proliferation,and immune responses.Age-related macular degeneration(ARMD),a prevalent retinal disease,has been significantly associated with disruptions in CR.ARMD is among the leading causes of vision loss in the elderly,with a complex pathogenesis involving multiple factors such as genetics,environmental influences,and lifestyle choices.This article will focus on the molecular mechanisms linking CR and ARMD,analyzing how disruptions in CR affect the physiological state and metabolic processes of retinal cells,ultimately contributing to the onset and progression of ARMD.Additionally,this article will elucidate the interactions effects of CR on ARMD in relation to oxidative stress,regulation of Aβ,inflammatory pathways,and mitochondrial homeostasis.By deepening our understanding of the relationship between CR and ARMD,we aim to provide new insights and directions for future clinical interventions and treatments.关键词
昼夜节律/年龄相关性黄斑变性/感光细胞/视网膜Key words
circadian rhythms/age-related macular degeneration/photoreceptor cells/retina引用本文复制引用
Wu Ziyang,Zou Wenjun..年龄相关性黄斑变性中的昼夜节律与其他影响因素的交互作用分析[J].国际眼科杂志,2026,26(1):50-55,6.基金项目
无锡市"双百"中青年医疗卫生拔尖人才项目(No.BJ2023036) Wuxi"Double Hundred"Program for Top Young and Middle-aged Medical and Health Talents(No.BJ2023036) （No.BJ2023036）
