皮肤性病诊疗学杂志2025，Vol.32Issue(12)：894-899,6.DOI:10.3969/j.issn.1674-8468.2025.12.009
胰岛素样生长因子-1在痤疮发病机制中的作用研究进展
Research progress on the role of insulin-like growth factor 1 in the pathogenesis of acne
摘要
Abstract
Acne is a common chronic,inflammatory disease of the pilosebaceous glands.Its pathogenesis is complex and affected by many factors.In recent years,the research on the patho-genesis of acne has been deepened.As a pleiotropic growth factor,insulin-like growth factor-1(IGF-1)plays an important role in the pathogenesis of acne.Studies have shown that IGF-1 can promote the proliferation and lipid synthesis of sebaceous gland cells by activating PI3K/Akt/mTORC1 signaling pathway,while also increasing androgen receptor sensitivity and aggravating se-baceous hypersecretion.This article reviews the current research progress on the role of IGF-1-me-diated inflammation in the pathogenesis of acne.关键词
痤疮/胰岛素样生长因子-1/机制/研究进展Key words
acne/insulin-like growth factor-1/pathogenesis/research progress引用本文复制引用
YANG Yuying,FANG Yali,LI Yuan..胰岛素样生长因子-1在痤疮发病机制中的作用研究进展[J].皮肤性病诊疗学杂志,2025,32(12):894-899,6.基金项目
山东省医药卫生科技发展计划项目(2019WS326) （2019WS326）
