皮肤性病诊疗学杂志2025，Vol.32Issue(12)：900-909,10.DOI:10.3969/j.issn.1674-8468.2025.12.010
铁死亡在白癜风发病中的作用研究进展
Research progress on the role of ferroptosis in the pathogenesis of vitiligo
摘要
Abstract
Vitiligo is a common depigmenting skin disorder with a complex pathogenesis,pri-marily resulting from the destruction,death,or dysfunction of melanocytes.In recent years,fer-roptosis,a novel iron-dependent form of cell death driven by lipid peroxidation,has been recog-nized as playing a significant role in the onset and progression of vitiligo.Factors such as iron ho-meostasis imbalance,lipid peroxidation accumulation,weakened antioxidant defenses,and activa-tion of immune inflammation collectively contribute to melanocyte damage.This review systemati-cally examines the physiological processes of iron metabolism,explores the molecular mechanisms of ferroptosis in melanocyte injury and its role in vitiligo pathogenesis,and summarizes potential therapeutic targets and drug interventions related to ferroptosis.An in-depth exploration of the in-teractions between ferroptosis and immune regulation provides novel insights and a strong theoreti-cal foundation for the precise prevention and treatment of vitiligo.关键词
白癜风/铁死亡/铁代谢/免疫调控/黑素细胞Key words
vitiligo/ferroptosis/iron metabolism/immune regulation/melanocytes引用本文复制引用
ZHUO Xiujuan,HUANG Xiuyun,SHI Xiaowei,LIU Han,ZHANG Jialin,FENG Jinlian..铁死亡在白癜风发病中的作用研究进展[J].皮肤性病诊疗学杂志,2025,32(12):900-909,10.基金项目
广东省中医药局面上项目(20251269) （20251269）
南方医科大学皮肤病医院苗圃项目(BR202408) （BR202408）
