南京医科大学学报（自然科学版）2026，Vol.46Issue(1)：31-38,46,9.DOI:10.7655/NYDXBNSN250909
老年结直肠癌患者术后辅助治疗与个体化治疗研究进展
Advances in postoperative adjuvant therapy and personalized treatment for elderly patients with colorectal cancer
摘要
Abstract
With the acceleration of global population aging,the disease burden of colorectal cancer(CRC)in the elderly is escalating.However,postoperative adjuvant therapy for this population suffers from a long-standing lack of robust medical evidence.Due to the unique physiological decline,high comorbidity burden,higher proportion of deficient mismatch repair/microsatellite instability-high(dMMR/MSI-H)and social psychological factors of the elderly,treatment decisions have become more complicated.Comprehensive geriatric assessment(CGA)serves as the core tool for achieving individualized treatment for the elderly CRC patients.For patients with poor physical condition,metronomic chemotherapy holds promise as a maintenance strategy with few side effects.Furthermore,intensified supportive treatment(encompassing management of bone marrow suppression,nutritional support,anti-cachexia drugs,structured exercise programs,and fecal microbiota transplantation)is crucial for ensuring treatment safety and life quality of patients.In summary,managing adjuvant therapy for elderly CRC patients must abandon the age-dependent model and shift towards individualized,precision strategies guided by CGA,balancing efficacy,side effects,and quality of life.Emerging directions such as immunotherapy,short-course chemotherapy,and organ preservation warrant attention.Future research should prioritize prospective studies specifically focused on the elderly population.关键词
结直肠癌/术后辅助治疗/老年综合评估/老年患者Key words
colorectal cancer/postoperative adjuvant therapy/comprehensive geriatric assessment/elderly patients分类
医药卫生引用本文复制引用
WU Xinyu,LING Rui,ZHU Wenyu..老年结直肠癌患者术后辅助治疗与个体化治疗研究进展[J].南京医科大学学报（自然科学版）,2026,46(1):31-38,46,9.基金项目
常州市第十一批科技计划项目(CJ20243019) （CJ20243019）
常州市卫健委科技项目(QN202320) （QN202320）
常州医学中心项目(CZKYCMCC202307) （CZKYCMCC202307）
