内科理论与实践2025，Vol.20Issue(5)：371-375,5.DOI:10.16138/j.1673-6087.2025.05.04
钠-葡萄糖耦联转运体2抑制剂降低早期糖尿病肾病患者的尿酸水平
Sodium-glucose linked transporter 2 inhibitors reduce serum uric acid in type 2 diabetic mellitus patients with early nephropathy
摘要
Abstract
Objective To explore the reducing serum uric acid(SUA)effects of dapagliflozin,a sodium-glucose linked transporter 2(SGLT2)inhibitor in patients with type 2 diabetes mellitus(T2DM)with early nephropathy and hyperuricemia.Methods Sixty-five patients with early T2 diabetic nephropathy and hyperuricemia admitted to our hospital from June 2020 to June 2023 were enrolled.After 4 weeks of treatment with dapagliflozin,a paired-sample T-test was used to analyze the changes in SUA,glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),serum creatinine(SCr),total cholesterol(TC),triglyceride(TG),urine albumin-to-creatinine ratio(UACR),body weight and other clinical indexes.Linear regression analysis was performed to determine the relationship between the changes of SUA before(baseline)and after treatment.Results In this group of 65 T2DM patients with early nephropathy and hyperuricemia,4 weeks of dapagliflozin reduced SUA[(436.1±39.5)vs(392.2±32.2)μmol/L,P<0.001],FPG[(7.66±2.23)vs(6.40±1.06)mmol/L,P<0.001],UACR[(211.3±73.2)vs(177.8±88.3)mg/g,P=0.005],and body weight[(63.1±9.7)vs(62.7±9.3)kg,P=0.038]significantly.Systolic blood pressure,diastolic blood pressure,HbA1c,TC,TG,SCr,estimated glomerular filtration rate(eGFR),and other levels were not changed(P>0.05).Linear regression analysis showed that the decreased levels of SUA positively correlated with the baseline levels of SUA(β=0.634,R2=0.401,P<0.001).Conclusions SGLT2 could effectively decrease blood glucose levels in patients with early T2DM nephropathy,and significantly reduce serum uric acid and urinary microalbumin.关键词
血尿酸/糖尿病肾病/钠-葡萄糖耦联转运体2抑制剂Key words
Serum uric acid/Diabetic nephropathy/Sodium-glucose linked transporter 2 inhibitors分类
医药卫生引用本文复制引用
WU Qianqian,GUO Jie,WANG Yifan,LIU Li,WANG Feng..钠-葡萄糖耦联转运体2抑制剂降低早期糖尿病肾病患者的尿酸水平[J].内科理论与实践,2025,20(5):371-375,5.基金项目
上海市第一人民医院基金项目(0206012418) （0206012418）
