陕西中医2026，Vol.47Issue(1)：133-136,4.DOI:10.3969/j.issn.1000-7369.2026.01.024
探讨"脑-肠轴"理论下中医药治疗卒中后抑郁研究进展
Research progress on the treatment of post-stroke depression based on the"Brain-Gut Axis"in traditional Chinese medicine
摘要
Abstract
Post-stroke depression refers to an affective disorder that occurs on the basis of cerebrovascular dis-ease.It not only has a poor prognosis,but also has a much higher mortality rate than stroke patients without depres-sion.There is increasing evidence that there is a two-way association between the brain and the gastrointestinal tract through the"brain-gut axis".Post-stroke depression is closely related to intestinal microbiota dysbiosis,intestinal barrier dysfunction and intestinal microbiota metabolites.Through literature analysis,it can be seen that traditional Chinese medicine therapy can interfere with brain-gut activity by affecting the"brain-gut axis",changing intestinal flora and metabolites,regulating neurotransmitter release,regulating the hypothalamus-pituitary adrenal axis,and reduc-ing immune inflammatory response,thereby improving the clinical symptoms of post-stroke depression.This article summa-rizes the treatment of post-stroke depression with traditional Chinese medicine from the perspective of"brain-gut axis"theo-ry,in order to provide a theoretical basis for the treatment of post-stroke depression with traditional Chinese medicine.关键词
"脑-肠轴"/卒中后抑郁/肠道菌群/中医药治疗/内治/外治Key words
"Brain-gut axis"/Post-stroke depression/Intestinal flora/Chinese medicine treatment/Internal governance/External treatment分类
医药卫生引用本文复制引用
XU Jing,HUI Zhenliang,ZHANG Xiaole,WANG Cui,MAO Jianhua..探讨"脑-肠轴"理论下中医药治疗卒中后抑郁研究进展[J].陕西中医,2026,47(1):133-136,4.基金项目
国家中医药管理局全国名老中医药专家传承工作室建设项目(2022) （2022）
陕西省重点研发计划项目(2024SF-YBXM-505) （2024SF-YBXM-505）
