世界科学技术-中医药现代化2025，Vol.27Issue(12)：3619-3630,12.DOI:10.11842/wst.20250803007
基于"乙癸同源"理论探讨形神共养法治疗膝骨关节炎共病抑郁状态的作用机制
Based on the Theory of"Yigui Homologous"to Explore the Mechanism of Body-spirit Co-nutrition in Regulating Knee Osteoarthritis with Depression
摘要
Abstract
Depression is a common comorbidity of knee osteoarthritis(KOA),a chronic degenerative joint disease that is highly prevalent among middle-aged and elderly populations.It has become a major public health challenge worldwide.For many patients,KOA brings not only joint pain and stiffness,but also may be accompanied by persistent low mood,loss of interest and motivation in life,and other typical depressive symptoms.In traditional Chinese medicine(TCM),the comorbidity of KOA and depression is understood through the theoretical framework of"Yigui Tongyuan"(a doctrine stating that the liver and kidney share a common origin).It holds that the two conditions interact with each other both physiologically and pathologically,and kidney deficiency,liver stagnation and blood stasis constitute the core pathogenesis of KOA comorbid with depressive state.For this pathogenesis,the corresponding therapeutic principle"tonifying the kidney,soothing the liver,and resolving blood stasis"is proposed in TCM to alleviate symptoms of both KOA and depression.Based on the theory of"Yigui Tongyuan"and modern medical research,this paper aims to explore the scientific basis and potential mechanisms of"Xingshen Gongyang"(body-spirit dual cultivation)approach in managing KOA with comorbid depression.关键词
"乙癸同源"理论/形神共养/膝骨关节炎/抑郁状态/共病Key words
"Yigui homologous"theory/"Xingshen Gongyang"(Body-spirit dual cultivation)/Knee osteoarthritis/Depression/Co-morbidity分类
医药卫生引用本文复制引用
WANG Yuqing,LI Shanshan,WANG Jiqing,FU Liying,DENG Hanzhi,XU Shifen,CHEN Lin,MI Yiqun..基于"乙癸同源"理论探讨形神共养法治疗膝骨关节炎共病抑郁状态的作用机制[J].世界科学技术-中医药现代化,2025,27(12):3619-3630,12.基金项目
国家自然科学基金面上项目(82474619):基于SIRT3介导的去乙酰化调控线粒体稳态探究温针灸治疗骨关节炎的作用机制,负责人:宓轶群 （82474619）
上海市中医药传承创新发展三年行动计划(ZY(2025-2027)-3-2-1):海派中医非药物疗法推广体系建设项目,负责人:宓轶群、张洁. （ZY(2025-2027）
