世界科学技术-中医药现代化2025，Vol.27Issue(12)：3643-3653,11.DOI:10.11842/wst.20250804001
针灸调控线粒体功能治疗膝骨关节炎机制的研究进展
Research Progress on the Mechanism of Acupuncture Regulation of Mitochondrial Function in Treating Knee Osteoarthritis
摘要
Abstract
Knee osteoarthritis(KOA)is a chronic joint disease that commonly affects middle-aged and elderly people.The accelerating aging of modern societies coupled with the growing severity of obesity issues have jointly driven up the incidence of KOA,creating a significant socioeconomic burden.The pathogenesis of KOA is not completely clear at present,but previous studies have found that mitochondrial dysfunction is an important factor leading to the onset of KOA.Mitochondrial quality control(MQC)can maintain the stability of mitochondrial morphology,number,and quality by regulating mitochondrial biogenesis processes,autophagy function,and redox pathways.Multiple studies have shown that acupuncture has made some progress in intervening in MQC.However,there is still a lack of systematic reviews on the regulation of MQC by acupuncture to intervene in KOA at present.To this end,this paper focuses on three core aspects of MQC-biogenesis,autophagy,and oxidative stress-to systematically review relevant research progress on acupuncture intervention for KOA.It aims to establish a robust and reliable theoretical foundation for the clinical application of acupuncture in the prevention and treatment of this condition.关键词
膝骨关节炎/线粒体质量控制/机制/针灸综述Key words
Knee osteoarthritis/Mitochondrial quality control/Mechanism/Acupuncture/Review分类
医药卫生引用本文复制引用
FU Liying,LI Bingrong,LI Shanshan,ZHANG Chaoyue,WANG Yuqing,XU Shifen,CHEN Lin,MI Yiqun..针灸调控线粒体功能治疗膝骨关节炎机制的研究进展[J].世界科学技术-中医药现代化,2025,27(12):3643-3653,11.基金项目
国家自然科学基金面上项目(82474619):基于SIRT3介导的去乙酰化调控线粒体稳态探究温针灸治疗骨关节炎的作用机制,负责人:宓轶群 （82474619）
上海市中医药传承创新发展三年行动计划(ZY(2025-2027)-3-2-1):海派中医非药物疗法推广体系建设项目,负责人:宓轶群、张洁. （ZY(2025-2027）
