世界科学技术-中医药现代化2025，Vol.27Issue(12)：3701-3707,7.DOI:10.11842/wst.20250804008
基于线粒体自噬探讨针灸治疗阿尔茨海默病的机制
Exploring the Mechanisms of Acupuncture Treatment for Alzheimer's Disease Based on Mitophagy
摘要
Abstract
Alzheimer's disease(AD)is a chronic neurodegenerative disorder characterized neuropathologically by progressive cognitive decline,mitochondrial dysfunction,and abnormal protein deposition.Recent research has identified defective mitophagy as a key link in the pathological progression of AD.Acupuncture has significant efficacy in improving cognitive function in AD.However,the precise mechanisms by which acupuncture exerts its neuroprotective effects through the regulation of mitophagy remain unclear.This article aims to systematically analyze,based on the latest research,the multifaceted mechanisms through which acupuncture influences mitochondrial function repair,activation of mitophagy pathways,improvement of energy metabolism,and inhibition of neuronal apoptosis.By integrating findings from animal models and experimental data,it explores the potential mechanisms by which acupuncture regulates mitophagy to prevent and treat AD.This analysis aims to provide novel insights for further systematic and in-depth investigation into the mechanisms of acupuncture treatment for AD.关键词
阿尔茨海默病/线粒体自噬/针灸/能量代谢/神经元凋亡Key words
Alzheimer's disease/Mitophagy/Acupuncture/Energy metabolism/Neuronal apoptosis分类
医药卫生引用本文复制引用
XU Huinan,YIN Xuan,ISHIKAWA AKI,FU Qifei,LI Wei,XU Shifen..基于线粒体自噬探讨针灸治疗阿尔茨海默病的机制[J].世界科学技术-中医药现代化,2025,27(12):3701-3707,7.基金项目
国家自然科学基金委员会面上项目(82274643):KMO调控Kyn-QA通路介导小胶质细胞活化及电针抗抑郁的神经保护机制研究,负责人:徐世芬 （82274643）
上海市卫生健康委员会上海市"医苑新星"青年医学人才培养资助计划(青年医师)[SHWSRS(2023)_062],负责人:殷萱. （青年医师）
