山西中医药大学学报2025，Vol.26Issue(11)：1199-1208,1228,11.DOI:10.19763/j.cnki.2096-7403.2025.11.06
基于数据挖掘及网络药理学的《圣济总录》治疗脾瘅的用药规律及作用机制
Exploration of medication patterns and mechanisms for spleen heat treatment in Shengji Zonglu through data mining and network pharmacology
摘要
Abstract
Objective:To summarize medication patterns and explore mechanisms of Shengji Zonglu formulations for spleen heat.Methods:SPSS Statistics and SPSS Modeler software analyzed 11 spleen heat formulas from Shengji Zonglu,identifying core prescriptions.Active components and targets were retrieved via TCMSP and PharmMapper databases,while disease targets were sourced from GenCard and OMIM.Protein-protein interaction(PPI)networks and herb-component-target-disease networks were constructed using STRING and Cytoscape 3.10.2.GO functional and KEGG pathway enrich-ment analyses were performed via DAVID.Results:Shengji Zonglu addresses spleen heat characterized primarily by vexing heat and thirst.Herbs exhibit predominantly cold or neutral properties;sweet,bitter,or pungent flavors;and lung,stom-ach,or spleen meridian tropism,with heat-clearing as the principal therapeutic action.The core prescription comprises Shigao,Danzhuye,Gancao,Baishao,and Xijiao.Key active components include quercetin,naringenin,isorhamnetin,and arginine.Critical targets involve TP53,Akt1,and STAT3.Major pathways encompass FoxO,PI3K-Akt,and MAPK signaling.Conclusion:Shengji Zonglu treats spleen heat primarily through heat-clearing mechanisms,with core prescrip-tions exerting synergistic effects via multi-component,multi-target,multi-pathway regulation.关键词
脾瘅/圣济总录/数据挖掘/网络药理学/用药规律/作用机制/清热Key words
spleen heat/Shengji Zonglu/data mining/network pharmacology/medication pattern/mechanism/heat-clearing分类
医药卫生引用本文复制引用
Zhu Shaohua,Zhao Jindong,Zhang Yi,Guo Mengzhu,Fang Zhaohui..基于数据挖掘及网络药理学的《圣济总录》治疗脾瘅的用药规律及作用机制[J].山西中医药大学学报,2025,26(11):1199-1208,1228,11.基金项目
新安医学与中医药现代化研究所"揭榜挂帅"项目(2023CXMMTCM024,2023CXMMTCM003) （2023CXMMTCM024,2023CXMMTCM003）
安徽省高等学校科学研究项目(2023AH050782) （2023AH050782）
安徽省卫生健康科研项目(AHWJ2023BAc10002) （AHWJ2023BAc10002）
2023年度新时代育人省级质量工程项目(研究生教育)建设项目(2023 gjxslt014) （研究生教育）
安徽省高校优秀拔尖人才培育项目(2022-371) （2022-371）
安徽省卫生健康骨干人才培养对象(2022-392) （2022-392）
安徽省名中医方朝晖工作室建设项目(2019-8-515) （2019-8-515）
