上海预防医学2025，Vol.37Issue(10)：803-812,10.DOI:10.19428/j.cnki.sjpm.2025.250215
上海市徐汇区社区人群新型冠状病毒重复感染的流行特征及影响因素
Epidemiological characteristics and influencing factors of SARS-CoV-2 reinfection in community populations in Xuhui District,Shanghai
摘要
Abstract
[Objective]To analyze the epidemiological characteristics and influencing factors of SARS-CoV-2 reinfection by conducting follow-up investigations among community residents who experienced their first SARS-CoV-2 infection between March and June 2022,so as to provide a scientific basis for predicting future epidemic trends and adjusting prevention and control strategies.[Methods]A cohort study was conducted in Xuhui District,Shanghai.A total of 1 208 individuals with a documented primary SARS-CoV-2 infection between March and June 2022 were enrolled and followed-up longitudinally.Data were collected using structured questionnaire surveys to assess the reinfection rate,incidence density,and clinical manifestations of SARS-CoV-2 reinfection.A logistic regression model was used to analyze the influencing factors of SARS-CoV-2 reinfection.[Results]A total of 497 SARS-CoV-2 reinfection cases were observed among the 1 208 research subjects,with a reinfection rate of 41.14%and an incidence density of 0.63 cases per 1 000 person-days.The cumulative reinfection rates at 6,9,12,15,and 18 months following the initial infection were 0.08%,15.31%,19.04%,33.53%,and 38.25%,respectively.Compared with the primary infection,reinfection was more likely to be symptomatic,with a greater severity of fever,dry cough,sore throat,and runny nose.Being female,younger age,and symptom duration≥7 days during the primary infection were identified as influencing factors for SARS-CoV-2 reinfection,while a higher socioeconomic status can reduce the risk of SARS-CoV-2 reinfection.[Conclusion]SARS-CoV-2 reinfection is relatively common and often symptomatic.Age,gender,income level,and the duration of symptoms during the primary infection are identified as infuencing factors for SARS-CoV-2 reinfection.Continuous monitoring of reinfection in the population is recommended,along with the development of effective strategies to mitigate the impact of reinfection.关键词
新型冠状病毒/重复感染/影响因素/Omicron变异株/队列研究Key words
SARS-CoV-2/reinfection/influencing factor/Omicron variant/cohort study分类
医药卫生引用本文复制引用
WANG Huiting,GUO Yanfei,CHEN Chen,YUE Junhong,JIA Qingqing,WU Fei,YIN Yanlu,ZANG Jiajie,WU Fan..上海市徐汇区社区人群新型冠状病毒重复感染的流行特征及影响因素[J].上海预防医学,2025,37(10):803-812,10.基金项目
国家重点研发计划项目(2023YFC0872600) （2023YFC0872600）
上海市加强公共卫生体系建设三年行动计划(2023-2025年)重点学科(GWVI-11.1-25) （2023-2025年）
上海市卫生健康委员会科研项目(202240081) （202240081）
