上海预防医学2025，Vol.37Issue(10)：813-816,820,5.DOI:10.19428/j.cnki.sjpm.2025.250209
2024-2025年浙江省慈溪市中小学生结核病感染现况
Screening analyses of tuberculosis infection among primary and secondary school students in Cixi City of Zhejiang Province from 2024 to 2025
摘要
Abstract
[Objective]To determine the prevalence and determinants of Mycobacterium tuberculosis latent infection among primary and secondary school students in Cixi City,Zhejiang Province,so as to provide references for the prevention and control of tuberculosis in school settings.[Methods]Interferon-γ release assay(IGRA)testing was performed to fourth-grade primary school students,as well as to those grade 7 and grade 10 students of the academic year 2024-2025 in Cixi City.Individuals tested positive for IGRA were subsequently subjected to chest X-ray examination and sputum tests(including three smear microscopy examinations and one mycobaterial culture),and epidemiological investigations were carried out for confirmed cases.Infection rates were compared across student categories by χ2 tests,while factors influencing infection were analysed through multivariate logistic regression.[Results]A total of 36 214 students completed tuberculosis screening,with an infection rate of 0.72%(260/36 214).The tuberculosis infection rates among fourth-grade primary school students,non boarding grade 7 students,boarding grade 7 students,grade 10 students of senior high school and of vocational high school were 0.68%(89/13 139),0.75%(86/11 501),0.51%(13/2 553),0.76%(52/6 819),and 0.91%(20/2 202),respectively.Multivariate logistic regression analyses indicated that students with a history of close contact with tuberculosis patients(OR=21.435,P＜0.001)had a higher risk of tuberculosis infection,students with a geographic origin outside Zhejiang Province(OR=1.485,P=0.002)had a higher risk of infection than those within Zhejiang Province.Furthermore,students from ethnic minority classes(OR=4.232,P＜0.001)might be high-risk groups for tuberculosis infection in high school settings.One IGRA-positive student was confirmed as bacteriologically positive pulmonary tuberculosis by liquid culture of sputum collected one month later.[Conclusion]Schools should prioritize tuberculosis screening.Students with a history of close contact,those with a geographic origin outside Zhejiang Province,and those enrolled in minority classes should be taken as priority targets for future tuberculosis screening programmes.A tracking and follow-up system must be established for IGRA-positive students to prevent persistent transmission of Mycobacterium tuberculosis within the school settings.关键词
学生/结核病筛查/γ-干扰素释放试验/分子生物学检测Key words
student/tuberculosis screening/gamma interferon release assay tests/molecular biological detection分类
医药卫生引用本文复制引用
WANG Linfeng,XU Sinan,LI Na,CHE Yang..2024-2025年浙江省慈溪市中小学生结核病感染现况[J].上海预防医学,2025,37(10):813-816,820,5.基金项目
宁波市公益性研究计划项目(2024S040) （2024S040）
慈溪市公益类科技计划项目(CN2022017) （CN2022017）
