宁夏大学学报（自然科学版）2025，Vol.46Issue(4)：327-334,8.DOI:10.20176/j.cnki.nxdz.20251201
一种近红外AIE荧光探针用于肿瘤脂滴成像及光动力治疗研究
A Near-Infrared AIE Fluorescent Probe for Tumor Lipid Droplet Imaging and Photo Dynamic Therapy
摘要
Abstract
Aggregation Induced Emission(AIE)materials have demonstrated significant potential in the bio-medical field due to their unique optical properties and structural tunability.Addressing the current challenges in cancer diagnosis and treatment,AIE materials exhibit remarkable performance in oncological applications.This study focuses on the design,synthesis,and biomedical applications of AIE theranostic agents.The TTM fluo-rescent molecule was synthesized via the Knoevenagel condensation reaction,and its molecular weight and photophysical properties were characterized.Subsequently,nano-self-assembly technology was employed to encapsulate the molecule into nanoparticles(TTM NPs).The hydrodynamic diameter and stability of TTM NPs were evaluated,and their cellular uptake behavior and photodynamic therapy(PDT)efficacy were assessed through cytotoxicity assays,confocal imaging,CCK-8 assays,and live-dead cell staining.The results show that the TTM molecules were successfully synthesized and exhibited excellent AIE properties.Further-more,TTM NPs demonstrated an appropriate size for drug delivery,good stability,efficient reactive oxygen species(ROS)generation,low biotoxicity,favorable fluorescence imaging characteristics,and notable PDT efficacy.In conclusion,this study successfully synthesized the AIE nanotheranostic agent TTM NPs,whose superior antitumor effects provide important theoretical support for the biomedical applications of AIE materi-als,and are expected to hold significant value in future clinical research.关键词
聚集诱导发光/荧光成像/光动力治疗/恶性肿瘤Key words
aggregation-induced emission/fluorescence imaging/photodynamic therapy/malignant tumors分类
医药卫生引用本文复制引用
HAN Yuanyuan,MA Qin,WU Ping,LU Xiaoli,WEI Yen..一种近红外AIE荧光探针用于肿瘤脂滴成像及光动力治疗研究[J].宁夏大学学报（自然科学版）,2025,46(4):327-334,8.基金项目
国家自然科学基金资助项目(52303189,U22A20144) （52303189,U22A20144）
宁夏自然科学基金优秀青年项目(2023AAC05027) （2023AAC05027）
银川市科技支撑重点项目(2024SFZD004) （2024SFZD004）
