陕西中医2026，Vol.47Issue(1)：40-47,8.DOI:10.3969/j.issn.1000-7369.2026.01.007
疏调稳糖平鼾方治疗痰浊郁热型2型糖尿病合并阻塞性睡眠呼吸暂停临床研究
Shutiao Wentang Pinghan formula in the treatment of type 2 diabetes mellitus combined with obstructive sleep apnea patients of phlegm-heat stagnation syndrome
摘要
Abstract
Objective:To evaluate the clinical efficacy and safety of Shutiao Wentang Pinghan formula in patients with Type 2 diabetes mellitus(T2DM)and obstructive sleep apnea(OSA)of phlegm-heat stagnation syndrome.Methods:A total of 88 patients with T2DM combined with OSA were randomly divided by the random number table method.The control group was given lifestyle intervention and conventional hypoglycemic,antihypertensive,lipid-lowering drugs and continuous positive airway pressure treatment.The experimental group was treated with the addi-tion of the Shutiao Wentang Pinghan formula on the basis of the control group.The treatment course for both groups was 12 weeks.HbA1c,FBG,2hPG,AHI,MSpO2,LSpO2,ODI,TC,TG,LDL-C,HDL-C,TyG,UA,SII,NLR,PLR,NPR,BMI,WHR,VAT,SAT,PSQI,ESS and TCM syndrome scores were measured at the time of enrollment and after 12 weeks of intervention.Safety was also evaluated.Results:After 12 weeks of treatment,the levels of HbA1c,FBG,2hPG,AHI,ODI,TC,TG,LDL-C,TyG,PSQI,ESS and TCM syndrome scores in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of MSpO2 and LSpO2 in the experimental group were higher than those in the control group,with statistically significant differences(P<0.05).There were no statistically significant differences in HDL-C,UA,BMI,WHR,VAT,SAT,SII,NLR and PLR between the two groups(P>0.05).The total efficacy rate of the experimental group was higher than that of the control group(P<0.05),and no serious adverse reactions were found in both groups.Conclusion:Shutiao Wentang Pinghan formula exhibit good clinical efficacy and safety in patients with T2DM combined with OSA of the phlegm-heat stagnation type.关键词
疏调稳糖平鼾方/小陷胸汤/解毒通络调肝方/2型糖尿病/阻塞性睡眠呼吸暂停/糖脂代谢/痰浊郁热Key words
Shutiao Wentang Pinghan formula/Xiaoxianxiong decoction/Jiedu Tongluo Tiaogan formula/Type 2 diabetes mellitus/Obstructive sleep apnea/Glycolipid metabolism/Phlegm-heat stagnation分类
医药卫生引用本文复制引用
CHEN Jiaqi,LIN Shuzhong,CHEN Zeyao,XU Jinghan,LIU Tianjiao,WANG Li,PIAO Chunli..疏调稳糖平鼾方治疗痰浊郁热型2型糖尿病合并阻塞性睡眠呼吸暂停临床研究[J].陕西中医,2026,47(1):40-47,8.基金项目
国家自然科学基金资助项目(82374380,82405256) （82374380,82405256）
中国中医药科技发展中心中西医协同慢病管理研究项目(CXZH2024170) （CXZH2024170）
广东省基础与应用基础研究基金资助项目(2023A1515220236) （2023A1515220236）
广东省深圳市"医疗卫生三名工程"项目资助(SZZYSM202202010) （SZZYSM202202010）
广东省深圳市福田区卫生健康系统科研项目(FTWS2022036,FTWS060) （FTWS2022036,FTWS060）
广州中医药大学深圳医院(福田)科研专项(GZYSY2024009) （福田）
