宁夏大学学报（自然科学版）2025，Vol.46Issue(4)：335-348,14.DOI:10.20176/j.cnki.nxdz.20251202
非经典蛋白分泌在病原体感染中的机制与作用
The Mechanisms and Functions of Unconventional Protein Secretion in Pathogen Infection
摘要
Abstract
Unconventional protein secretion(UcPS)refers to the release of proteins that occurs independently of the classical endoplasmic reticulum-Golgi secretory pathway.This process primarily involves direct translo-cate across the plasma membrane,export mediated by ABC transporters,vesicle-mediated secretion and the Golgi-bypass pathway.Proteins secreted via UcPS can engage in signal transduction,immune regulation and"moonlighting"activities that differ from their functions within the cell.These proteins participate in various pathological processes,including inflammatory responses,neurodegenerative diseases and tumors.Recent stud-ies have demonstrated that UcPS plays an important role in pathogen infections,with both pathogens and host cells utilizing this pathway to secrete effector molecules or immune factors,thereby affecting infection establish-ment,immune evasion and host defense.The regulation of UcPS is closely linked to the onset and progression of various infectious diseases.This article systematically reviews the types and molecular mechanisms of UcPS,emphasizing its functions and mechanisms in pathogen-host interactions.关键词
非经典蛋白分泌/病原体感染/病原体-宿主互作/免疫调节Key words
unconventional protein secretion/pathogen infection/pathogen-host interaction/immune regula-tion分类
生物科学引用本文复制引用
ZHU Yuhe,LIU Lei..非经典蛋白分泌在病原体感染中的机制与作用[J].宁夏大学学报（自然科学版）,2025,46(4):335-348,14.基金项目
国家自然科学基金资助项目(32200553) （32200553）
西安交通大学高层次人才引进项目(青年拔尖人才(B类)) （青年拔尖人才(B类）
