塔里木大学学报2025，Vol.37Issue(6)：9-23,15.DOI:10.3969/j.issn.1009-0568.2025.06.002
精氨酸参与合成的天然产物结构、功能及其生物合成途径
The structures,functions,and biosynthetic pathways of natural products synthesized with arginine involvement
摘要
Abstract
Arginine is extensively involved in the biosynthesis of natural products,serving as a source of key structural units for numerous bioactive molecules.This contribution has facilitated the generation of a variety of structurally diverse compounds with significant biological importance,including polyketides,non-ribosomal peptides,ribosomal peptides,β-lactams,and aminoglycosides.A unifying feature of these compounds is the presence of arginine-derived guanidino or amino groups in their structures,which are crucial to the molecules'bioactivity.In biosynthesis,arginine can be incorporated into products through various mechanisms:modification into 4-guanidinobutyrate as a starter unit for polyketide synthesis;incorporation as an amino acid substrate into non-ribosomal peptide chains;enzymatic modification during the post-translational modifications of peptides;and participation in specialized cyclization steps(such as β-lactam ring formation).These arginine-derived natural products exhibit broad-spectrum antimicrobial and antifungal activities,highlighting their substantial value for the development of anti-infective drugs.This review systematically summarizes the types,structural characteristics,biosynthetic mechanisms,and biological activities of natural products synthesized with arginine involvement,providing a theoretical foundation for the development of novel drugs.关键词
精氨酸/天然产物/结构特征/生物活性/生物合成Key words
arginine/natural products/structural characteristics/biological activity/biosynthesis分类
生物科学引用本文复制引用
SUN Zhibin,WAN Chuanxing..精氨酸参与合成的天然产物结构、功能及其生物合成途径[J].塔里木大学学报,2025,37(6):9-23,15.基金项目
塔里木大学研究生科研创新项目(TDGRI202309) （TDGRI202309）
