妇儿健康导刊2025，Vol.4Issue(24)：47-50,63,5.DOI:10.3969/j.issn.2097-115X.2025.24.008
川崎病合并巨噬细胞活化综合征患儿的临床特征分析
Analysis of clinical characteristics of children with Kawasaki disease complicated with macrophage activation syndrome
摘要
Abstract
Objective To analyze the clinical characteristics of children with Kawasaki disease complicated with macrophage activation syndrome(KD-MAS),and to provide a basis for the early identification of KD-MAS.Methods A total of 65 children with Kawasaki disease(KD)in Children's Hospital Affiliated to Shandong University from January 2020 to December 2024 were selected as the research subjects.Among them,those with macrophage activation syndrome(MAS)were included in the KD-MAS group(13 cases),and those without MAS were included in the KD group(52 cases).The clinical manifestations and laboratory indicators of the two groups were compared.Results The proportions of hepatomegaly,splenomegaly and no response to intravenous immunoglobulin(IVIG)in the KD-MAS group were higher than those in the KD group(P<0.05).The hemoglobin(Hb),platelets(PLT),erythrocyte sedimentation rate(ESR),albumin(ALB),and fibrinogen(FIB)in the KD-MAS group were lower than those in the KD group,the differences were statistically significant(P<0.05).The alanine aminotransferase(ALT),aspartate aminotransferase(AST),monocyte count(MONO),triglyceride(TG),ferritin(SF),D-dimer(D-D),and the ratio of monocyte to high-density lipoprotein cholesterol(MHR)in the KD-MAS group were higher than those in the KD group,the differences were statistically significant(P<0.05).Conclusion Children with KD-MAS often have hepatomegaly,splenomegaly and no response to IVIG.Laboratory tests show elevated ALT,AST,MONO,TG,SF,D-D,and MHR,while decreased Hb,PLT,ESR,ALB,and FIB.For suspected KD-MAS children,clinicians should conduct a comprehensive assessment and dynamically monitor key laboratory indicators to make an early diagnosis and timely intervention.关键词
川崎病/巨噬细胞活化综合征/临床特征/儿童Key words
Kawasaki disease/Macrophage activation syndrome/Clinical characteristic/Children分类
医药卫生引用本文复制引用
LI Yunxi,WANG Xue..川崎病合并巨噬细胞活化综合征患儿的临床特征分析[J].妇儿健康导刊,2025,4(24):47-50,63,5.基金项目
济南市卫生健康委员会科技计划项目(2023-2-145). （2023-2-145）
