天津中医药2026，Vol.43Issue(1)：44-50,7.DOI:10.11656/j.issn.1672-1519.2026.01.08
针灸在肿瘤靶向和免疫治疗中的辅助价值:机制探讨、临床实践及未来方向
Adjuvant value of acupuncture in targeted therapy and immunotherapy:Mechanisms,clinical practice,and future directions
摘要
Abstract
Targeted therapy and immunotherapy have emerged as hotspots in anti-tumor research in recent years,yet limitations persist,including driver gene negativity,low PD-L1 expression,post-treatment resistance,and adverse reactions to targeted and immunotherapy.While research foundations for acupuncture-assisted surgery and radiotherapy/chemotherapy are relatively robust,studies on acupuncture-assisted targeted and immunotherapy remain scarce.We summarized the mechanisms,clinical practice,and future directions of acupuncture-assisted targeted immunotherapy.Mechanisms include:1)enhancing patient immune function to sensitize immunotherapy(boosting immune function during radiotherapy and chemotherapy,strengthening perioperative immune function to reduce postoperative inflammatory responses,alleviating treatment-related tumor complications,and preventing tumor recurrence);2)modulating the tumor immune microenvironment to help reverse immune suppression;3)regulating pathways related to tumor-targeted immunotherapy,particularly modulating the PD-1/PD-L1 pathway.Clinical applications include:1)enhancing the antitumor efficacy of targeted immunotherapy;2)alleviating skin toxicity associated with epidermal growth factor inhibitors;3)treating gastrointestinal adverse reactions;4)improving cancer-related fatigue;5)boosting immune function and enhancing quality of life.Finally,we summarized the current limitations in acupuncture research supporting targeted immunotherapy for tumors and identifies future research challenges.关键词
针刺/艾灸/靶向治疗/免疫治疗Key words
acupuncture/moxibustion/targeted therapy/immunotherapy分类
医药卫生引用本文复制引用
HU Yuxing,ZHANG Zexing,HE Ziyan,WANG Tianlin,CHANG Xuesong,HE Yihan,ZHANG Haibo..针灸在肿瘤靶向和免疫治疗中的辅助价值:机制探讨、临床实践及未来方向[J].天津中医药,2026,43(1):44-50,7.基金项目
国家重点研发计划"中医药现代化"专项课题(2023YFC3503303) （2023YFC3503303）
广州地区中西医协同临床重大创新技术建设项目[穗卫函(2023)2318号] （2023）
广州市科技计划项目(2025A03J4133) （2025A03J4133）
广州地区中医药重大科技项目(2025ZD007) （2025ZD007）
大学生创新创业训练计划(202510572021,202510572106,202510572225). （202510572021,202510572106,202510572225）
