天津中医药2026，Vol.43Issue(1)：62-66,5.DOI:10.11656/j.issn.1672-1519.2026.01.11
基于长夏溃疡结肠炎的发病机制探讨"脾应长夏"的生物学内涵
Discussion on the biological connotation of"spleen corresponding to late summer"based on the pathogenesis of ulcerative colitis in late summer
摘要
Abstract
The aberrant intestinal flora in the season of late summer can mediate the macrophages M1/M2 polarization imbalance of macrophages through ROS/HIF-1α pathway,thus inducing the occurrence of ulcerative colitis(UC).Based on the pathogenesis of UC in the season of late summer,this paper discusses the biological connotation of"spleen corresponding to late summer",in order to clarify the biological essence of"spleen corresponding to late summer"and reveal the scientific connotation of"correspondence between man and universe".In addition,the imbalance mechanism of the regulatory chain of"intestinal microbiota-ROS/HIF-1α-macrophage M1/M2 polarization"provides a new diagnosis and treatment target for the prevention and treatment of seasonal UC.关键词
脾应长夏/溃疡性结肠炎/巨噬细胞/ROS/HIF-1αKey words
spleen corresponding to late summer/ulcerative colitis/macrophage/ROS/HIF-1α分类
医药卫生引用本文复制引用
HE Xue,SUN Yike,LIU Leilei..基于长夏溃疡结肠炎的发病机制探讨"脾应长夏"的生物学内涵[J].天津中医药,2026,43(1):62-66,5.基金项目
国家自然科学基金青年项目(82104706). （82104706）
