畜牧兽医学报2025，Vol.56Issue(12)：5952-5962,11.DOI:10.11843/j.issn.0366-6964.2025.12.002
基因修饰技术及其在牛羊抗病育种中的应用
Gene Modification Technology and Its Application in Breeding for Disease Resistance in Cattle and Small Ruminants
摘要
Abstract
Gene modification refers to the precise editing of an organism's DNA sequence through human intervention in order to modify its genomic structure or function in a targeted manner.In recent years,with the development of molecular biology and genetic engineering technology,gene modification technology(e.g.,transgenic technology and gene editing technology)com-bined with assisted reproduction technology has shown great potential in the field of disease-resistant breeding in cattle and small ruminants.This technology can not only precisely improve disease resistance traits and enhance the health and production performance of livestock but also make up for the shortcomings of traditional selection and breeding methods in terms of low effi-ciency and long cycle time.However,compared with disease resistance breeding in pigs and chickens,cattle and small ruminants still have more room for progress in this field.Currently,optimizing the genome of cattle and Small ruminants through gene modification technology is be-coming a cutting-edge direction to break through the bottleneck of traditional prevention and con-trol.The review describe the current development of gene modification technology from the as-pects of animal transgenics and gene editing technology and briefly summarize the status of the application of this technology in disease resistance breeding in cattle and small ruminants,which will provide some references for future research on disease resistance breeding in cattle and small ruminants.关键词
抗病育种/转基因/基因编辑Key words
disease resistance breeding/transgenics/gene editing分类
农业科技引用本文复制引用
CAO Jinping,CAI Zexi,LI Lingfeng,LIU Guangbin..基因修饰技术及其在牛羊抗病育种中的应用[J].畜牧兽医学报,2025,56(12):5952-5962,11.基金项目
广东省农业农村厅清远黑山羊标准化养殖技术与全产业链产品开发综合研究项目 （）
