畜牧兽医学报2025，Vol.56Issue(12)：6025-6033,9.DOI:10.11843/j.issn.0366-6964.2025.12.008
5-HT调控畜禽神经行为异常及肠道功能紊乱的研究进展
Research Advances in 5-HT Regulation of Neurobehavioral Abnormalities and Gastrointestinal Dysfunction in Livestock and Poultry
摘要
Abstract
The gastrointestinal tract is the largest microecosystem in animals,where complex mi-crobial communities constitute the animal's intestinal microbial barrier.5-Hydroxytryptamine(5-HT),commonly known as serotonin,is a neurotransmitter in animals,with more than 90%produced by the intestine,which exhibits various biological functions including the regulation of intestinal peristalsis,secretion processes,immune responses,and maintenance of intestinal barri-er integrity.As a pivotal signaling molecule in the gut-brain axis,5-HT can transmit information through the nervous,endocrine,and immune systems;thus playing a vital role in maintaining neural and intestinal homeostasis while modulating disease states.Currently,research on 5-HT mainly focuses on fields such as biology,medicine,ethology,and psychology,however,studies pertaining to its implications in livestock and poultry remain scarce.This paper systematically re-views the regulatory mechanisms of 5-HT in neurological abnormal behaviors and intestinal disea-ses of rodents,livestock,and poultry.It also discusses the regulation of intestinal 5-HT synthe-sis and microbial balance by adding tryptophan precursors such as rumen-protected 5-hydroxytryptophan(5-HTP),probiotics,or plant extracts(such as Astragalus polysaccharide,natural capsaicin)to alleviate intestinal disorders such as post-weaning diarrhea in piglets and necrotic enteritis in broilers.Under stress scenarios such as heat stress or transport stress,enhancing 5-HT levels via probiotic supplementation or regulating intestinal 5-HT receptor gene expression through colostrum feeding can mitigate stress-induced behavioral abnormalities and immune dysfunctions.These findings aim to provide theoretical support for practical applications in animal husbandry.关键词
5-HT/肠道菌群/肠-脑轴/神经性异常行为/肠道炎症Key words
5-HT/gut microbiota/gut-brain axis/neurobehavioral disorders/intestinal inflam-mation分类
农业科技引用本文复制引用
MA Dengjun,CHEN Jiaxin,ZHOU Ruilin,WANG Lihong,LI Huifeng,LIU Xintian,YANG Zhenguo..5-HT调控畜禽神经行为异常及肠道功能紊乱的研究进展[J].畜牧兽医学报,2025,56(12):6025-6033,9.基金项目
国家自然科学基金项目(31902167) （31902167）
重庆市教委科学技术研究项目(KJQN202300226) （KJQN202300226）
西南大学大学生创新创业训练计划资助项目(S202210635347) （S202210635347）
国家生猪技术创新中心先导科技项目(NCTIP-XD/B02) （NCTIP-XD/B02）
