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PFKFB成员在泛癌的表达及其与肿瘤免疫和药物敏感性分析

LIAO Siyu SONG Yanlun HUANG Shaofeng WANG Jian HUANG Yuehua ZHANG Xin ZHU Shiman QU Chiwen WANG Rong

右江医学2025，Vol.53Issue(12)：1070-1074,5.

右江医学2025，Vol.53Issue(12)：1070-1074,5.DOI:10.3969/j.issn.1003-1383.2025.12.002

PFKFB成员在泛癌的表达及其与肿瘤免疫和药物敏感性分析

Analysis of expression of PFKFB members in pan-cancer and its relationship with tumor immunity and drug sensitivity

LIAO Siyu ¹SONG Yanlun ²HUANG Shaofeng ²WANG Jian ²HUANG Yuehua ¹ZHANG Xin ¹ZHU Shiman ²QU Chiwen ²WANG Rong¹

作者信息

1. Department of Blood Transfusion,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China||Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions,Baise 533000,Guangxi,China||Department of Clinical Hematology and Morphology of School of Medical Technology and Artificial Intelligence,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China
2. Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions,Baise 533000,Guangxi,China||Department of Clinical Hematology and Morphology of School of Medical Technology and Artificial Intelligence,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China
折叠

摘要

Abstract

Objective To explore the immune and drug sensitivity regulatory effects of fructose-2,6-diphosphatase(PFKFB)on tumors,and to analyze the gene expression,immune subtypes,and drug sensitivity of PFKFB family members,so as to provide new knowledge for cancer treatment targets.Methods Data for 33 cancer types,including RNA-seq,clini-cal phenotypes,and immune subtypes,were downloaded from the cancer genome atlas(TCGA).Cell data and RNA sequencing data were obtained from CellMiner and processed using Perl and R languages and their packages.Wilcoxon test was used to process and analyze the sequencing data downloaded from the TCGA database.Results The expression of PFKFB family members exhibited different heterogeneity in different cancers.PFKFB1,PFKFB3,and PFKFB4 predicted poor prognosis in patients with multiple cancers,and all members were associated with immune response.Research had found that PFKFB2 and PFKFB4 might promote drug resistance in cancer cells.Conclusion Based on gene expression and its correlation with immune infiltration and tumor microenvironment,members of the PFKFB family have specific roles in each type of cancer,and PFKFB2 and PFKFB4 may serve as targets for cancer therapy.

关键词

果糖-2,6-二磷酸酶(PFKFB)/免疫亚型/药物敏感性/泛癌

Key words

fructose-2,6-biphosphatase(PFKFB)/immune subtype/drug sensitivity/pan-cancer

分类

医药卫生

引用本文复制引用

LIAO Siyu,SONG Yanlun,HUANG Shaofeng,WANG Jian,HUANG Yuehua,ZHANG Xin,ZHU Shiman,QU Chiwen,WANG Rong..PFKFB成员在泛癌的表达及其与肿瘤免疫和药物敏感性分析[J].右江医学,2025,53(12):1070-1074,5.

基金项目

国家自然科学基金(62341210) （62341210）

广西自然科学基金(2025GXNSFHA069073) （2025GXNSFHA069073）

右江医学

ISSN：1003-1383

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