右江医学2025，Vol.53Issue(12)：1091-1098,8.DOI:10.3969/j.issn.1003-1383.2025.12.005
多模态超声技术在卵圆孔未闭诊断中的应用效果评估
Evaluation of the application effect of multimodal ultrasound techniques in the diagnosis of patent foramen ovale
摘要
Abstract
Objective To investigate the application effect and clinical value of multimodal ultrasound techniques(tran-sthoracic echocardiography[TTE],contrast transthoracic echocardiography[c-TTE],contrast-enhanced transcranial Doppler ultrasound[c-TCD],and combined c-TTE+c-TCD examination)in the diagnosis of patent foramen ovale(PFO)and right-to-left shunt(RLS).Methods A total of 68 patients diagnosed with PFO by TEE who visited Liuzhou People's Hospital due to cryptogenic stroke or migraine from May 2022 to May 2024 were retrospectively enrolled.The detection sensi-tivity and shunt grading of RLS by multimodal ultrasound techniques in resting state and after Valsalva maneuver were com-pared,and the correlation between RLS grade and the inner diameter of the bilateral opening and tunnel length of PFO was analyzed.Results The detection sensitivities of c-TTE(95.59％)and c-TCD(88.24％)for PFO(RLS)were significant-ly higher than that of TTE(13.24％,all P<0.001),and the sensitivity of combined examination reached 97.06％.After Valsalva maneuver,the detection rates of c-TTE and combined examination significantly increased(P<0.05).In grade Ⅲshunt,the detection rates of c-TTE and combined examination were higher than that of c-TCD(P<0.05).Correlation analy-sis showed that in c-TTE,the diameters of the openings on both atrial sides of PFO were positively correlated with RLS grade(P<0.05);in combined examination,the tunnel length of PFO and the diameter of the left atrial opening were positively correlated with RLS grade(P<0.05).Conclusion Multimodal ultrasound techniques have important value in the diagnosis and treatment of PFO.The combined examination is non-invasive and reproducible,and can be combined with standard Val-salva maneuver to improve the detection rate.It may serve as the preferred screening tool for patients with cryptogenic stroke or migraine,and provide an effective alternative diagnostic option for those who are contraindicated for TEE.The evaluation of PFO morphology and shunt grade by c-TTE and combined examination can provide scientific basis for early clinical diagno-sis,treatment decision-making,and prognosis evaluation.关键词
卵圆孔未闭/多模态超声技术/经胸超声心动图右心声学造影(c-TTE)/对比增强经颅多普勒超声(c-TCD)/c-TTE联合c-TCD检查/右向左分流/分流等级Key words
patent foramen ovale(PFO)/multimodal ultrasound techniques/contrast transthoracic echocardiography(c-TTE)/contrast-enhanced transcranial Doppler ultrasound(c-TCD)/combined c-TTE+c-TCD examination/right-to-left shunt(RLS)/shunt grading分类
医药卫生引用本文复制引用
LI Bin,XIAO Caiyi,HUANG Huiying,WEI Xianbin,WU Jing..多模态超声技术在卵圆孔未闭诊断中的应用效果评估[J].右江医学,2025,53(12):1091-1098,8.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200173) （Z20200173）
