眼科学报2025，Vol.40Issue(11)：893-901,9.DOI:10.12419/25041103
获得性免疫缺陷综合征合并巨细胞病毒性视网膜炎抗病毒治疗后眼内液特征分析
Analysis of characteristics of intraocular fluid following antiviral treatment for acquired immunodeficiency syndrome complicated by cytomegalovirus retinitis
摘要
Abstract
Objective:To investigate the intraocular fluid characteristics of acquired immunodeficiency syndrome(AIDS)complicated with cytomegalovirus retinitis(CMVR)after antiviral treatment.Method:A retrospective analysis was conducted on the clinical data of 49 patients with AIDS and concomitant CMVR admitted to our hospital from November 2018 to December 2024.They were divided into a control group(n=23,30 eyes)and a combination group(n=26,30 eyes)according to different treatment methods.The control group received systemic antiviral treatment with intravenous sodium phosphonate,while the combination group received intravitreal injection of ganciclovir(GCV)on this basis.The intraocular fluid characteristics of the two groups were compared.Result:After treatment,the levels of CMV nucleic acid load,interleukin-6,IL-8,IL-10,vascular endothelial growth factor(VEGF),basic fibroblast growth factor(BFGF),and vascular cell adhesion molecule(VCAM)in the intraocular fluid of both groups were lower than before treatment,and the combined group was lower than the control group(P<0.05);No HSV was detected in both groups before and after treatment EBV、VZV、HHV-6.Spearman correlation analysis showed that the CMV nucleic acid load in aqueous humor was positively correlated with IL-6,IL-8,IL-10,VEGF,BFGF,and VCAM(P<0.05).Conclusion:AIDS patients with CMVR showed better efficacy after systemic and local antiviral treatment,and exhibited significant decreases in CMV nucleic acid load and related cytokines in aqueous humor.关键词
获得性免疫缺陷综合征/巨细胞病毒性视网膜炎/抗病毒治疗/眼内液特征Key words
acquired immune deficiency syndrome/cytomegalovirus retinitis/antiviral therapy/characteristics of intraocular fluid分类
医药卫生引用本文复制引用
JIANG Yaoqi,LI Linghua,ZHANG Wanqi,WANG Xiaoli,LIU Xinqi..获得性免疫缺陷综合征合并巨细胞病毒性视网膜炎抗病毒治疗后眼内液特征分析[J].眼科学报,2025,40(11):893-901,9.基金项目
广东省医学科研基金(B2018138).This work was supported by Guangdong Provincial Medical Research Fund Project(B2018138). （B2018138）
