眼科学报2025，Vol.40Issue(11)：902-909,8.DOI:10.12419/25072103
铜绿假单胞菌感染性眼内炎的临床特点及耐药性分析
Clinical characteristics and analysis of antimicrobial resistance in Pseudomonas aeruginosa-induced endophthalmitis
TAN Yiwei 1JIANG Jinliang 1LIAO Jingyu 1DUAN Fang1
作者信息
- 1. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China
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摘要
Abstract
Objective:To explore the clinical characteristics and antibiotic resistance patterns of endophthalmitis induced by Pseudomonas aeruginosa at our hospital from January 2013 to December 2024,with the aim of providing evidence to support the rational clinical use of antimicrobial agents.Methods:A retrospective analysis was conducted on patients diagnosed with Pseudomonas aeruginosa endophthalmitis at Zhongshan Ophthalmic Center,Sun Yat-sen University,during the period from January 2013 to December 2024.Clinical features and antibiotic resistance profiles of the patients were documented and analyzed.Results:Among the 44 patients,2 received conservative treatment.The remaining 42 patients underwent surgical intervention:13 patients received intravitreal antibiotic injection combined with vitrectomy,10 patients underwent vitrectomy alone,and 19 patients required enucleation.Post-treatment visual outcomes were as follows:1 patient achieving 20/400 vision,3 patients had with finger count(FC)vision,9 with hand move(HM),5 patients with light perception(LP),and 26 patients with no light perception(NLP).In vitro drug susceptibility tests revealed that Pseudomonas aeruginosa was 100.0%sensitive to amikacin,meropenem and tobramycin;97.5%sensitive to gentamicin;95.0%sensitive to levofloxacin and ciprofloxacin;80.0%sensitive to cefepime and imipenem;75.0%sensitive to ceftazidime and ofloxacin;and 0%sensitive to chloramphenicol,cefazolin,cefuroxime,ceftriaxone and cotrimoxazole.Conclusions:The visual prognosis of patients with Pseudomonas aeruginosa endophthalmitis remains poor,with a high rate of enucleation.The pathogen demonstrated favorable susceptibility to amikacin,meropenem,and tobramycin.关键词
眼内炎/铜绿假单胞菌/抗菌药物/耐药性Key words
entophthalmitis/Pseudomonas aeruginosa/antimicrobial resistance分类
医药卫生引用本文复制引用
TAN Yiwei,JIANG Jinliang,LIAO Jingyu,DUAN Fang..铜绿假单胞菌感染性眼内炎的临床特点及耐药性分析[J].眼科学报,2025,40(11):902-909,8.
