眼科学报2025，Vol.40Issue(11)：945-952,8.DOI:10.12419/25022302
Fuchs葡萄膜炎综合征的眼部结构改变
Ocular structural changes in Fuchs uveitis syndrome
摘要
Abstract
Fuchs uveitis syndrome is a chronic anterior uveitis that predominantly impacts the anterior segment of the eye.Since its etiology remains unclear,diagnosis largely relies on clinical manifestations.Consequently,alternations in ocular structure play a pivotal role in both the diagnosis and treatment of this disease.Due to the persistent nature of chronic inflammation,a range of structural changes occur,spanning from the cornea and anterior chamber to retina and choroid.This article provides a detailed account of the characteristic changes in the anterior segment.In the cornea,characteristic keratic precipitates are observable,accompanied by a reduction in endothelial cell density and morphological alterations.The anterior chamber exhibits aqueous flashes and cells,where inflammatory factors and viruses can be detected.Additionally,characteristic iris atrophy is visible,presenting as depigmentation and altered autofluorescence.These three factors collectively reflect the inflammatory state and progress with the course,potentially offering insights into the etiological mechanism.Concurrent cataract and floates,which are common complications associated with recurrent inflammation,accompanied by structural changes in the lens and vitreous.Structural alterations at the vitreol enticular interface,located between the posterior lens capsule and anterior vitreous,provide valuable clues regarding the pathogenesis of complications and provide new perspectives for therapeutic strategies.The structural changes in the fundus of Fuchs syndrome are often insidious.While it remains undetermined whether the retinal thickness in the macular region undergoes changes,numerous studies suggest a decrease in retinal blood flow density.Thinning of the ganglion cell layer in the optic disc may be linked to concurrent glaucoma.The choroid also experiences changes in the thickness of vascular layer and blood flow density,which could be a manifestation of chronic inflammation.In conclusion,numerous questions regarding the ocular structural changes in Fuchs uveitis syndrome still await further exploration.关键词
Fuchs葡萄膜炎综合征/角膜/虹膜/晶状体/视网膜/脉络膜Key words
Fuchs uveitis syndrome/cornea/iris/lens/retina/choroid分类
医药卫生引用本文复制引用
ZHOU Fangyue,JIN Cheng,WANG Yuqin..Fuchs葡萄膜炎综合征的眼部结构改变[J].眼科学报,2025,40(11):945-952,8.基金项目
国家自然科学基金(82271076).This work was supported by National Natural Science Foundation of China(82271076). （82271076）
