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中国三省农村地区室内PM2.5暴露与代谢综合征关系研究

JI Qingyuan TIAN Maoyi ZHANG Hanbin YE Pengpeng LIU Tingzhuo DU Xue WANG Tengyi LI Xiaoying TIAN Wei ZHANG Xinyi

医学新知2025，Vol.35Issue(12)：1387-1397,11.

医学新知2025，Vol.35Issue(12)：1387-1397,11.DOI:10.12173/j.issn.1004-5511.202507221

中国三省农村地区室内PM2.5暴露与代谢综合征关系研究

Association with PM2.5 exposure and metabolic syndrome:a cross-sectional study in rural areas in three provinces of China

JI Qingyuan ¹TIAN Maoyi ²ZHANG Hanbin ³YE Pengpeng ⁴LIU Tingzhuo ¹DU Xue ¹WANG Tengyi ¹LI Xiaoying ⁵TIAN Wei ⁶ZHANG Xinyi⁷

作者信息

1. School of Public Health,Harbin Medical University,Harbin 150000,China
2. School of Public Health,Harbin Medical University,Harbin 150000,China||Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin 150000,China||NHC Key Laboratory of Etiology and Epidemiology,Harbin 150000,China||Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health,Harbin 150000,China||Department of General Practice,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China
3. European Centre for Environment and Human Health,University of Exeter Medical School,Truro TR10 8RD,UK||Environmental Research Group,MRC Centre for Environment and Health,Faculty of Medicine,Imperial College London Medical School,London W12 0BZ,UK
4. National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China
5. Department of Mechanical Engineering,Colorado State University,Fort Collins,Colorado 80523,USA
6. Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin 150000,China||NHC Key Laboratory of Etiology and Epidemiology,Harbin 150000,China||Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health,Harbin 150000,China
7. School of Public Health,Harbin Medical University,Harbin 150000,China||Department of General Practice,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China
折叠

摘要

Abstract

Objective To evaluate the association between indoor PM2.5 exposure and metabolic syndrome(MetS)in rural areas of three provinces in China.Methods This cross-sectional study was conducted across 240 villages in three Chinese provinces.Participants aged≥30 years were randomly selected through gender-and age-stratified sampling in each village.Sociodemographic characteristics,lifestyle habits,medical history,and residential environment features were collected via standardized questionnaires.The prevalence of MetS was assessed based on blood pressure,waist circumference,and fasting venous blood biochemical indices.Indoor PM2.5 concentrations were assessed using PM2.5 monitoring devices that provided continuous 24-hour monitoring over seven days.Multivariable Logistic regression models were constructed to analyze the relationship between PM2.5 exposure levels and MetS risk,with dose-response relationships explored using restricted cubic spline models.Subgroup analysis and sensitivity analysis were also conducted simultaneously.Results A total of 958 participants were included in the study,with a prevalence of MetS of 54.91%.After adjusting for confounders,participants exposed to the highest levels of PM2.5 exhibited significantly elevated MetS risk compared to the lowest exposure[OR=1.62,95%CI(1.16,2.26)].Subgroup analyses revealed heightened susceptibility to high PM2.5 exposure among females[OR=2.28,95%CI(1.39,3.75)],individuals aged 50～<60 years[OR=2.08,95%CI(1.14,3.80)],low level of education[OR=1.99,95%CI(1.33,3.52)],low level of income[OR=2.26,95%CI(1.20,4.25)],exposure to household second-hand smoke[OR=1.58,95%CI(1.10,2.27)],those cooking for 1～2 h/d[OR=1.78,95%CI(1.12,2.82)]and individuals engaged in light physical labor[OR=1.55,95%CI(1.07,2.26)].Sensitivity analyses confirmed the robustness of these findings.Conclusion Elevated indoor PM2.5 exposure is associated with increased MetS risk in rural China,highlighting the need for targeted interventions to address household air pollution and improve indoor air quality.

关键词

代谢综合征/细颗粒物/室内空气监测/中国农村/横断面研究

Key words

Metabolic syndrome/Particulate matter 2.5/Indoor air monitoring/Rural China/Cross-sectional study

分类

医药卫生

引用本文复制引用

JI Qingyuan,TIAN Maoyi,ZHANG Hanbin,YE Pengpeng,LIU Tingzhuo,DU Xue,WANG Tengyi,LI Xiaoying,TIAN Wei,ZHANG Xinyi..中国三省农村地区室内PM2.5暴露与代谢综合征关系研究[J].医学新知,2025,35(12):1387-1397,11.

基金项目

哈尔滨医科大学领军人才资助项目(31021220002)本研究对加拿大麦吉尔大学的Prof.Jill Baumgartner团队及科罗拉多州州立大学的Prof.Ellison Carter团队提供空气污染采样器设备表示衷心感谢.感谢中国科学院大学薛凯兵同学帮助协调本研究的空气污染采样器物流.感谢北京大学环境学院朱彤教授及左澎老师为本研究空气污染采样器校准提供支持和指导.作者张汉彬在进行此研究期间受英国医学研究理事会环境与健康中心授予的职业早期研究员基金资助(资助编号:MR/T502613/1) （31021220002）

医学新知

ISSN：1004-5511

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