医学新知2025，Vol.35Issue(12)：1464-1470,7.DOI:10.12173/j.issn.1004-5511.202507038
溶瘤病毒疗法在泌尿系肿瘤中的研究进展
Progress of oncolytic virus therapy in urological cancers
摘要
Abstract
Oncolytic virus(OV)therapy is an emerging anti-tumor therapeutic approach in which the virus can selectively replicate and destroy tumor cells without damaging normal cells.The virus stimulates the anti-tumor immunoreactive responses by releasing antigens and activating inflammatory responses in the tumor microenvironment.Despite recent advancements in the treatment of advanced urinary tract tumors,subsequent-line treatment options remain limited,and the disease faces clinical challenges such as high recurrence rates and drug resistance.Therefore,there is an urgent need to develop safer and more effective novel treatment strategies and drugs.This article reviews the latest research progress on OV therapy in the treatment of urinary tract tumors,systematically outlining their application prospects,current challenges,and future development directions.关键词
溶瘤病毒疗法/溶瘤效应/免疫治疗/泌尿系肿瘤/前列腺癌/膀胱癌/肾癌Key words
Oncolytic virus therapy/Oncolytic effect/Immunotherapy/Urological cancers/Prostate cancer/Bladder cancer/Kidney cancer分类
医药卫生引用本文复制引用
ZHAO Heng,DU Ling,WEI Fang,WANG Mengqin,SHOU Zhanyi,FENG Shengyi,WANG Lei..溶瘤病毒疗法在泌尿系肿瘤中的研究进展[J].医学新知,2025,35(12):1464-1470,7.基金项目
国家自然科学基金青年科学基金项目(81902597) （81902597）
浙江省医药卫生科技计划项目(2023KY677) （2023KY677）
吴阶平医学基金(320.6750.2020-10-88) （320.6750.2020-10-88）
