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麒麟竭中黄烷类化合物及其对心肌细胞损伤保护作用

SUN Yunjiao LI Jun PANG Daoran YIN Jiaojiao WANG Yuan ZHANG Yuyan LI Junjun LIN Yue WU Zihao HUO Huixia

中草药2026，Vol.57Issue(1)：24-30,7.
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中草药2026，Vol.57Issue(1)：24-30,7.DOI:10.7501/j.issn.0253-2670.2026.01.003

麒麟竭中黄烷类化合物及其对心肌细胞损伤保护作用

Flavans from Daemonorops draco and their myocardial cell protective activity

SUN Yunjiao 1LI Jun 1PANG Daoran 1YIN Jiaojiao 1WANG Yuan 1ZHANG Yuyan 1LI Junjun 1LIN Yue 1WU Zihao 2HUO Huixia3

作者信息

  • 1. School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China||Modern Research Center for Traditional Chinese Medicine,Beijing Institute of Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China
  • 2. School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China
  • 3. Modern Research Center for Traditional Chinese Medicine,Beijing Institute of Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China
  • 折叠

摘要

Abstract

Objective To investigate the chemical constituents and their myocardial cell protective activity from the fruits of Daemonorops draco.Methods Compounds were isolated and purified using a combination of silica gel,RP-C18,Sephadex LH-20 and semi-preparative HPLC.Their structures were elucidated through comprehensive spectroscopic analysis,UV,IR,HRESIMS and NMR.The protective effects of all isolates on the H9c2 myocardial cells injury induced by oxygen-glucose deprivation(OGD)were evaluated.Results Three pairs of new flavans were purified and elucidated as(2S)-2-ethoxy-7-hydroxy-5-methoxy-6-methylflavan(1a),(2R)-2-ethoxy-7-hydroxy-5-methoxy-6-methylflavan(1b),(2S,3S)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan(2a),(2R,3R)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan(2b),(2R,3S)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan(3a)and(2S,3R)-2-ethoxy-3,7-dihydroxy-5-methoxy-6-methylflavan(3b).Compounds 1b and 2b demonstrated protective effects against OGD-induced H9c2 cell injury,which increased cell viability by(6.36±1.26)%and(10.78±0.76)%at a concentration of 20 μmol/L,respectively.Conclusion Compounds 1a/1b,2a/2b,and 3a/3b are three pairs of enantiomers,and they are all new compounds,named as dracoropin I1,dracoropin I2,dracoropin J1,dracoropin J2,dracoropin K1,dracoropin K2.Among them,compounds 1b and 2b exhibited protective effects on myocardial cells.

关键词

麒麟竭/黄烷类化合物/对映异构体/缺糖缺氧/心肌细胞保护活性/麒麟竭素I2/麒麟竭素J2/麒麟竭素K1

Key words

Daemonorops draco Bl./flavans/enantiomer/oxygen-glucose deprivation/myocardial cell protective activity/dracoropin I2/dracoropin J2/dracoropin K1

分类

医药卫生

引用本文复制引用

SUN Yunjiao,LI Jun,PANG Daoran,YIN Jiaojiao,WANG Yuan,ZHANG Yuyan,LI Junjun,LIN Yue,WU Zihao,HUO Huixia..麒麟竭中黄烷类化合物及其对心肌细胞损伤保护作用[J].中草药,2026,57(1):24-30,7.

基金项目

国家自然科学基金重点项目(82030114) （82030114）

国家中医药管理局青年岐黄学者培养项目([2022]256) （[2022]256）

中草药

0253-2670

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