中草药2026，Vol.57Issue(1)：31-38,8.DOI:10.7501/j.issn.0253-2670.2026.01.004
枸杞子中1个新的吡咯生物碱
A new pyrrole alkaloid from fruit of Lycium barbarum
摘要
Abstract
Objective To research the chemical constituents from the fruits of Lycium barbarum.Methods Separation and purification were performed using silica gel,D-101 macroporous resin,MCI,Sephadex LH-20,and semi-preparative HPLC.The structures of the compounds were identified based on spectroscopic data and physicochemical properties.The α-glucosidase inhibitory activity of the selected compounds was evaluated using 4-nitrophenol-α-D-glucopyranoside(PNPG)assay.Results A total of 15 compounds were isolated from the fruits of L.barbarum,which were identified as methyl(2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate(1),5-epi-acortatarin A(2),5-(methoxymethyl)-1H-pyrrole-2-carbaldehyde(3),4-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid(4),(2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(4-hydroxyphenyl)propanoate(5),4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoate(6),3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid(7),N-trans-feruloyl-3′-O-methyldopamine(8),N-trans-feruloyl-3′,4′-dihydroxyphenylethylamine(9),N-cis-p-coumaroyl tyramine(10),N-cis-feruloyl tyramine(11),bungeanoline E(12),N-malonyl-tryptophan(13),3-hydroxy-4-ethyl ketone pyridine(14),cartorimine(15).Conclusion Compound 1 is a new pyrrole alkaloid,named lycipyrrole A.Compound 2 is a new natural product.Compounds 4,7 and 12-15 were isolated from L.barbarum for the first time,while compounds 12,13 and 15 were isolated from this genus for the first time.Notably,compound 9 exhibited significant inhibitory activity against α-glucosidase.关键词
茄科/枸杞子/生物碱/α-葡萄糖苷酶抑制活性/枸杞吡咯碱A/5-epi-acortatarin A/3-羟基-4-乙基酮吡啶Key words
Solanaceae/Lycium barbarum L./alkaloids/α-glucosidase inhibitory activity/lycipyrrole A/5-epi-acortatarin A/3-hydroxy-4-ethyl ketone pyridine分类
医药卫生引用本文复制引用
ZHAO Yongzhuo,NIU Ying,MA Yuguo,LIU Hui,SUN Jiaxin,HAO Zhiyou,FENG Weisheng,CHEN Hui..枸杞子中1个新的吡咯生物碱[J].中草药,2026,57(1):31-38,8.基金项目
国家自然科学基金资助项目(22177027) （22177027）
河南省高校科技创新团队支持计划(24IRTSTHN039) （24IRTSTHN039）
河南省杰出青年科学基金项目(252300421027) （252300421027）
