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三七花中1个新异香豆素

YANG Ping WANG Xinxin SHANG Jiahuan ZHU Hongtao ZHAO Ping ZHU Guolei ZHANG Yingjun

中草药2026，Vol.57Issue(1)：39-44,6.

中草药2026，Vol.57Issue(1)：39-44,6.DOI:10.7501/j.issn.0253-2670.2026.01.005

三七花中1个新异香豆素

A new isocoumarin isolated from flower buds of Panax notoginseng

YANG Ping ¹WANG Xinxin ²SHANG Jiahuan ²ZHU Hongtao ²ZHAO Ping ³ZHU Guolei ³ZHANG Yingjun²

作者信息

1. Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China,Southwest Forestry University,Kunming 650224,China||Key Laboratory of Phytochemistry and Natural Medicines,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China
2. Key Laboratory of Phytochemistry and Natural Medicines,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China
3. Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China,Southwest Forestry University,Kunming 650224,China
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摘要

Abstract

Objective To study the non-saponin chemical constituents of the flower buds of Panax notoginseng and evaluate their antioxidant and anti-inflammatory activities.Methods The extraction was performed by refluxing with 65%aqueous ethanol,followed by successive liquid-liquid extraction with petroleum ether,ethyl acetate(EtOAc)and n-butanol.The compounds were isolated and purified using RP-18,silica gel,MCI gel CHP20P,Sephadex LH-20 column chromatography and semi-preparative liquid chromatography.Structural identification was carried out by comprehensive analysis of nuclear magnetic resonance(NMR)spectroscopy,high-resolution mass spectrometry(HR-MS),ultraviolet(UV)spectroscopy,and computational electronic circular dichroism(ECD)spectroscopy.Some purified compounds were evaluated for preliminary antioxidant activity and anti-inflammatory activity.Results A total of seven non-saponin components were isolated from the EtOAc fraction of P.notoginseng flower buds,including one isocoumarin(1),four simple phenols(2-5),and two loliolides(6,7),were obtained from the EtOAc fraction.These were identified as isocoumarin F1(1),ferulic acid(2),evofolin A(3),p-hydroxybenzoic acid(4),4-hydroxybenzaldehyde(5),(+)-epiloliolide(6),and(-)-loliolide(7),respectively.Conclusion All compounds(1-7)were isolated from P.notoginseng for the first time.Of which,compound 1 is a new isocoumarin and named isocoumarin F1,while compound 2 exhibited obvious DPPH radical scavenging ability.

关键词

三七花/异香豆素类/简单酚类/抗氧化/抗炎/异香豆素F1/阿魏酸/4-羟基苯甲醛/黑麦草内酯

Key words

flower buds of Panax notoginseng/isocoumarin/phenolics/antioxidant activity/anti-inflammatory/isocoumarin F1/ferulic acid/4-hydroxybenzaldehyde/(-)-loliolide

分类

医药卫生

引用本文复制引用

YANG Ping,WANG Xinxin,SHANG Jiahuan,ZHU Hongtao,ZHAO Ping,ZHU Guolei,ZHANG Yingjun..三七花中1个新异香豆素[J].中草药,2026,57(1):39-44,6.

基金项目

云南省科技厅重点研发计划(202203AC100008) （202203AC100008）

植物化学与西部植物资源持续利用国家重点实验室课题(P2022-KF15) （P2022-KF15）

中草药

ISSN：0253-2670

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