摘要
Abstract
Lung cancer is one of the most prevalent and lethal malignant tumors worldwide,with lung adenocarci-noma(LUAD)being a major subtype.In recent years,research has revealed that the tumor microenvironment(TME)plays a crucial role in the development and progression of LUAD.Notably,the role of neutrophils has increasingly garnered attention.Studies have shown that neutrophils can differentiate into various phenotypes within the TME,exhibiting multiple pro-tumor-igenic functions.Additionally,neutrophils can secrete neutrophil extracellular traps(NETs)in response to certain stimuli.Al-though NETs possess anti-tumor characteristics,an increasing number of studies have uncovered their multifaceted pro-tumor functions.This review describes the role of neutrophils in the initiation,development,and metastasis of LUAD,focusing on immunoregulation,cellular metabolism,genetics,and various molecular mechanisms.关键词
肺肿瘤/中性粒细胞/肿瘤微环境/中性粒细胞胞外诱捕网/分子机制Key words
Lung neoplasms/Neutrophils/Tumor microenvironment/Neutrophil extracellular traps/Molecular mechanism
