中国肺癌杂志2025，Vol.28Issue(10)：777-786,10.DOI:10.3779/j.issn.1009-3419.2025.102.41
自噬与铁死亡在肺癌发生发展及治疗中的研究进展
Research Advances on the Autophagy and Ferroptosis in the Development and Treatment of Lung Cancer
摘要
Abstract
Lung cancer remains a life-threatening malignancy with complex pathogenesis.This paper provides a systematic review of autophagy and ferroptosis-related signaling pathways,key regulatory factors,and their associated mecha-nisms,including the nuclear receptor coactivator 4(NCOA4)-mediated ferritin autophagy-ferroptosis axis,mitochondrial autophagy,lipid droplet autophagy,circadian autophagy,chaperone-mediated autophagy,etc..The review elucidates the roles of the tumor microenvironment and non-coding RNAs in autophagy-ferroptosis processes in lung cancer.Furthermore,it explores the potential of modern drugs and active components from traditional Chinese medicine to improve lung cancer out-comes by targeting autophagy and ferroptosis,proposing that targeting their interactive pathways could offer novel therapeutic strategies for lung cancer.关键词
肺肿瘤/自噬/铁死亡/信号通路/非编码RNAKey words
Lung neoplasms/Autophagy/Ferroptosis/Signaling pathway/Non-coding RNA引用本文复制引用
Chengqi JIANG,Xueping CUI,Li ZHENG,Chengkun DENG,Ruoshan HUANG,Bo HOU,Junfeng WANG..自噬与铁死亡在肺癌发生发展及治疗中的研究进展[J].中国肺癌杂志,2025,28(10):777-786,10.基金项目
This paper was supported by the grant from Science and Technology Plan Project of the Yunnan Provincial Depart-ment of Science and Technology(No.202401AY070001-370)(to Junfeng WANG). 本文受云南省科技厅科技计划项目(No.202401AY070001-370)资助 （No.202401AY070001-370）
