中国实验方剂学杂志2026，Vol.32Issue(1)：1-11,11.DOI:10.13422/j.cnki.syfjx.20251927
补肾法治疗泛血管"免疫-代谢-遗传"轴机制
Mechanism of Kidney-tonifying Therapy in Treating Panvascular Disease Through"Immune-metabolic-genetic"Axis
摘要
Abstract
Pan vascular disease(PVD)is a systemic vascular disorder that has become the leading cause of death among the Chinese residents,and there is currently a lack of effective systemic treatment options.Clinical practice has found that the traditional Chinese medicine(TCM)method of kidney tonification can effectively intervene in PVD and target key pathological mechanisms of PVD recognized in Western medicine.Accordingly,this paper conducts research from the following three aspects:First,it clarifies that immune dysregulation,metabolic disorders,and genetic susceptibility constitute the core pathological mechanisms of PVD in Western medicine.Typical pathological manifestations include progressive vascular endothelial injury,lipid deposition,and plaque formation,ultimately leading to multi-organ damage and dysfunction.PVD activates pathways such as the NOD-like receptor thermal protein domain-associated protein 3(NLRP3)inflammasome,triggering immune dysregulation;it also induces disorders of mitochondrial energy metabolism,water-salt metabolism,and hormonal metabolism,synergizing with genetic susceptibility factors(e.g.,apolipoprotein E gene)to accelerate vascular homeostasis imbalance.Second,this study analyzes the intrinsic relationship between the TCM theory of"kidney deficiency"and the"immune-metabolic-genetic"axis,revealing the theoretical basis for kidney tonification in intervening PVD.The kidney stores essence,governs bones,and produces marrow,which is related to the generation and differentiation of immune cells.It regulates Qi transformation and governs water,overseeing material and energy metabolism.The kidney is the root of congenital essence and governs reproduction,closely related to genetic mechanisms.Third,by integrating modern clinical research,this study elaborates on the unique advantages and clinical value of kidney tonification in targeting the"immune-metabolic-genetic"axis of heart,brain,and kidney organs.Traditional kidney-tonifying formulas and their active ingredients improve immune-inflammatory responses,enhance material and energy metabolism homeostasis,and modulate epigenetic pathways through multiple pathways,targeting various pathways to intervene in PVD.This study systematically elucidates the scientific connotation of kidney tonification in treating PVD,providing theoretical support and practical guidance for integrated TCM-Western medicine approaches and contributing to innovation and improvement in diagnostic and treatment strategies for PVD.关键词
泛血管疾病/免疫-代谢-遗传/病理机制/补肾法/中医治疗Key words
panvascular disease/immune-metabolic-genetic/pathological mechanism/kidney-tonifying method/traditional Chinese medicine treatment分类
医药卫生引用本文复制引用
SUN Xuan,WANG Jie,ZHANG Zhenpeng,LIU Lanchun,LIU Yongmei,LIU Chao..补肾法治疗泛血管"免疫-代谢-遗传"轴机制[J].中国实验方剂学杂志,2026,32(1):1-11,11.基金项目
国家自然科学基金重点项目(82230124) （82230124）
中央高水平中医医院临床科研业务项目(HLCMHPP2023083) （HLCMHPP2023083）
国家中医药管理局第二届全国名中医传承工作室建设项目(国中医药办人教函[2022]245号) （国中医药办人教函[2022]245号）
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
国家自然科学基金青年基金项目(82305221) （82305221）
