中国实验方剂学杂志2026，Vol.32Issue(1)：23-29,7.DOI:10.13422/j.cnki.syfjx.20251928
基于"伏邪"理论探讨泛血管疾病发病机制及防治策略
Exploring Pathogenesis,Prevention and Treatment Strategies of Panvascular Diseases Based on"Latent Pathogen"Theory
摘要
Abstract
Panvascular diseases refer to systemic vascular lesions with atherosclerosis as its common pathological basis,affecting the vascular networks of multiple organs such as the heart,brain,kidneys,limbs,and large arteries.This concept transcends the limitations of traditional classifications and promotes comprehensive vascular health management through multidisciplinary collaboration.Latent pathogenic factors play a critical role in the pathogenesis of panvascular diseases.They remain dormant within the body until finding an opportunity to manifest,which aligns closely with the characteristics of panvascular diseases,including their early covert progression and subsequent adverse vascular events.According to the"latent pathogen"theory,this article elucidates the pathogenesis of panvascular diseases from latent pathogen,vessel damage,and healthy Qi consumption.It posits that the disease onset involves a pathological process progressing from Qi to blood,with endothelial injury serving as the initiating factor.Disease progression encompasses changes from blood to vessels,with inflammatory responses accelerating the disease course.A comprehensive traditional Chinese medicine(TCM)based prevention and treatment system has been developed,dividing the disease course into three stages.In the early stage,pathogenic factors lurk in the vessels,primarily manifesting as abnormal lipid metabolism.In the middle stage,pathogenic factors evolve,leading to inflammatory cascade reactions.In the late stage,pathogenic factors become excessive while positive factors decline,resulting in abnormal energy metabolism.Three core therapeutic approaches-invigorating the spleen and resolving phlegm,activating blood and resolving stasis,and reinforcing healthy Qi and nourishing deficiency-have been established to address key pathological links.In conjunction with modern medical research,the mechanisms of these methods in regulating lipid metabolism,inhibiting inflammatory responses,and modulating energy metabolism to prevent and treat panvascular diseases are explained.It is anticipated that this theoretical framework will enrich the diagnostic and therapeutic thinking in TCM for panvascular diseases and provide a theoretical foundation for constructing TCM-characteristic prevention and treatment plans for panvascular diseases.关键词
伏邪/泛血管疾病/中医药/病机/防治策略Key words
latent pathogens/panvascular disease/traditional Chinese medicine/pathogenesis/prevention and treatment strategies分类
医药卫生引用本文复制引用
ZHANG Ruoqi,WANG Jie,LIU Lanchun,LIU Chao..基于"伏邪"理论探讨泛血管疾病发病机制及防治策略[J].中国实验方剂学杂志,2026,32(1):23-29,7.基金项目
国家自然科学基金重点项目(82230124) （82230124）
中央高水平中医医院临床科研业务项目(HLCMHPP2023083) （HLCMHPP2023083）
国家中医药管理局第二届全国名中医传承工作室建设项目(国中医药办人教函[2022]245号) （国中医药办人教函[2022]245号）
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
国家自然科学基金青年基金项目(82305221) （82305221）
