中国输血杂志2025，Vol.38Issue(12)：1695-1701,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.12.007
红细胞单采术用于治疗高原红细胞增多症的研究
Erythrocytapheresis for the treatment of high-altitude polycythemia
摘要
Abstract
Objective To investigate the efficacy and incidence of adverse reactions of therapeutic erythrocytapheresis in high altitude polycythemia(HAPC)population.Methods A retrospective study was conducted on 243 HAPC patients who were either native residents or long-term workers in Xizang and underwent therapeutic erythrocytapheresis in the Cheng-du Office Hospital of the People's Government of Xizang Autonomous Region from 2021 to 2023.A comparative study was carried out on the changes in blood routine,vital signs,skin color,serum iron metabolism data,and the incidence of ad-verse reactions before and after the procedure.Results After erythrocytapheresis,significant decreases were observed in red blood cell(RBC)count(7.06±0.89× 1012 vs 6.08±0.93× 1012/L,P＜0.001],hemoglobin(HGB,211.59±17.99 vs 182.76±19.83 g/L,P＜0.001),hematocrit(Hct)[(65.30±6.45)％vs(55.56±8.12)％,P＜0.001],serum iron(14.46±4.38 vs 11.77±3.78 μmol/L,P=0.003),total iron-binding capacity(126.62±4.47 vs 123.73±3.77 μmol/L,P=0.002),transferrin(1.88±0.41 vs 1.77±0.12 g/L,P=0.023),transferrin saturation[(11.32±3.11)％vs(9.43±2.78)％,P=0.004],serum ferritin(832.4±295.6 vs 665.3±249.2 ng/mL,P＜0.001),systolic blood pressure(123.86±14.43 vs 118.51±13.68 mmHg,P＜0.001)and diastolic blood pressure(81.68±9.54 vs 74.28±7.61 mmHg,P＜0.001).In contrast,platelet count(Pit,137.21±46.21 ×109 vs 147.94±50.66 ×109/L,P＜0.001)and oxygen satu-ration[(93.97±3.29)％vs(95.84±2.27)％,P＜0.001]increased.No significant differences were found in white blood cell(WBC)count[5.35(4.59,6.44)× 109/L vs 5.43(4.54,6.53)× 109/L,P=0.690],unsaturated iron-binding capacity(112.15±0.50 vs 111.96±0.25 μmol/L,P=0.074)and pulse rate(73.42±11.28 vs 73.19±7.18 beats/min,P=0.750).Furthermore,skin color of the face(conjunctiva,lips)and palms mitigated after therapeutic erythrocytaphere-sis,changing from purplish-red to red.The total incidence of adverse reactions during erythrocytapheresis was 13.98％(34/243),including citrate toxicity 12.75％(31/243),puncture site hematoma 0.82％(2/243)and blood volume im-balance 0.41％(1/243).Conclusion Therapeutic erythrocytapheresis could rapidly decrease HCT,Hb,serum iron,transferrin and transferrin saturation levels in HAPC patients,with a low incidence of adverse reactions.Therefore,thera-peutic erythrocytapheresis has broad clinical application prospects in Xizang Autonomous Region.关键词
高原红细胞增多症/红细胞单采术/铁代谢/生命体征/不良反应Key words
high-altitude polycythemia/erythrocytapheresis/iron metabolism/vital signs/adverse reactions分类
医药卫生引用本文复制引用
LONG Wenchun,WAN Dongmei,FAN Wuyi,LI Xuexue,YE Yan,SUN Zengmei,LI Tingting,HE Zeng,SUN Xueping..红细胞单采术用于治疗高原红细胞增多症的研究[J].中国输血杂志,2025,38(12):1695-1701,7.基金项目
西藏自治区人民政府驻成都办事处医院院级课题(2023-YJ-14) （2023-YJ-14）
西藏科技厅揭榜挂帅项目(XZ202303ZY0011G) （XZ202303ZY0011G）
