中国实验方剂学杂志2026，Vol.32Issue(1)：30-38,9.DOI:10.13422/j.cnki.syfjx.20251922
基于"正虚痰瘀"理论探讨线粒体稳态失调与泛血管疾病的关系
Exploration in Relationship Between Mitochondrial Homeostasis Dysregulation and Panvascular Diseases Based on Theory of"Positive Deficiency Phlegm Stasis"
摘要
Abstract
Panvascular diseases represent systemic vascular disorders characterized by atherosclerosis as their core pathological feature.Their incidence rates continue to rise,posing significant challenges for clinical management.Based on Traditional Chinese Medicine(TCM)theory of"positive deficiency phlegm stasis",this study delved into the pivotal role of mitochondrial homeostasis dysregulation in the pathogenesis and progression of pan-vascular diseases,along with its intrinsic connection to TCM pathogenesis.Mitochondrial homeostasis dysregulation pervades the entire course of these diseases,with mitochondrial oxidative stress serving as the initiating factor.Excessive reactive oxygen species(ROS)trigger endothelial dysfunction,lipid accumulation,and inflammatory initiation.Additionally,the imbalance between mitochondrial autophagy and apoptosis constitutes a pivotal link in disease progression.Excessive or insufficient autophagy may lead to the accumulation of damaged mitochondria and excessive cellular apoptosis,thereby promoting plaque instability.Furthermore,mitochondrial metabolic reprogramming impairs energy supply and function in vascular wall cells,hindering subsequent vascular repair.These pathological processes constitute the microscopic manifestation of the core pathogenesis,which is characterized by"the intermingle of phlegm and stasis and the deficiency of healthy Qi".Specifically,the endogenous phlegm-turbidity drives mitochondrial oxidative stress injuries,the mutual entanglement of phlegm and stasis induces an imbalance between mitochondrial autophagy and apoptosis,while deficiency of healthy Qi propels mitochondrial energy metabolism disorders and reprogramming.In view of this,this study proposed to employ phlegm-resolving and turbidity-clearing methods to mitigate mitochondrial oxidative stress injuries,phlegm-resolving and blood-activating methods to regulate mitochondrial autophagy and apoptosis,and spleen-tonifying and kidney-nourishing methods to modulate mitochondrial metabolic reprogramming.This approach can prevent and treat panvascular diseases by multi-target regulation of mitochondrial homeostasis,providing a theoretical framework and therapeutic strategies for the prevention and treatment of panvascular diseases through integrated Chinese and Western medicine.关键词
痰瘀/正气虚损/线粒体/动脉粥样硬化/泛血管Key words
phlegm stasis/deficiency of healthy Qi/mitochondria/atherosclerosis/panvascular分类
医药卫生引用本文复制引用
LI Hongping,WANG Jie,ZHANG Zhenpeng,LIU Chao,LIU Lanchun,HOU Chengzhi..基于"正虚痰瘀"理论探讨线粒体稳态失调与泛血管疾病的关系[J].中国实验方剂学杂志,2026,32(1):30-38,9.基金项目
国家自然科学基金重点项目(82230124) （82230124）
中央高水平中医医院临床科研业务项目(HLCMHPP2023083) （HLCMHPP2023083）
国家中医药管理局第二届全国名中医传承工作室建设项目(国中医药办人教函[2022]245号) （国中医药办人教函[2022]245号）
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
国家自然科学基金青年基金项目(82305221) （82305221）
