中国临床医学影像杂志2025，Vol.36Issue(12)：869-873,5.DOI:10.12117/jccmi.2025.12.008
实时三维斑点追踪成像技术评价糖尿病肾病患者左心房容积及功能改变
Evaluation of left atrial volume and functional changes in patients with diabetic nephropathy using real-time three-dimensional speckle tracking imaging
摘要
Abstract
Objective:To investigate the application value of real-time three-dimensional speckle tracking imaging(RT3D-STI)in evaluating changes of left atrial volume and function in patients with diabetic nephropathy(DN).Method:A total of 131 patients with diabetic nephropathy(DN group)treated at Nantong Third People's Hospital from January 2022 to September 2024 were selected as the study subjects.Additionally,97 patients with type 2 diabetes mellitus(T2DM group)and 97 healthy volunteers(control group)during the same period were included.The patients in DN group were divided into early group(n=69)and middle-late group(n=62)according to Mogenson stage.Conventional parameters were measured using two-dimensional echocardiography.Left atrial structural parameters,functional parameters,and strain parameters were obtained using RT3D-STI.Results:There were no statistically significant differences in conventional parameters such as left atrial diameter(LAD),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),and the ratio of early diastolic mitral inflow velocity(E)to late diastolic mitral inflow velocity(A)among the three groups(P＞0.05).Comparisons of left atrial structural parameters,including maximum left atrial volume(LAVmax),minimum left atrial volume(LAVmin),and pre-contraction left atrial volume(LAVpre),showed DN group＞T2DM group＞control group(P<0.05).Comparisons of functional parameters,including left atrial ejection fraction(LAEF),left atrial active ejection fraction(LAaEF),and left atrial passive ejection fraction(LApEF),showed DN group<T2DM group<control group(P<0.05).Comparisons of strain parameters,including left atrial reservoir strain(LASr),left atrial conduit strain(LAScd),and left atrial contractile strain(LASct),showed DN group<T2DM group<control group(P<0.05).The levels of LAVmax,LAVmin,and LAVpre in the middle-to-late stage group were higher than those in the early-stage group(P<0.05),while the levels of LAEF,LAaEF,LApEF,LASr,LAScd,LASct,and left atrial reservoir circumferential strain(LASr-c)were lower than those in the early-stage group(P<0.05).Conclusion:RT3D-STI can detect changes in left atrial volume and function in DN patients earlier than conventional two-dimensional echocardiography.In DN patients,left atrial volume significantly increases,left atrial function is altered,and strain values decrease.关键词
糖尿病肾病/心房功能,左/超声心动描记术Key words
Diabetic Nephropathies/Atrial Function,Left/Echocardiography分类
医药卫生引用本文复制引用
GU Xing-xing,SI Tong,ZHU Jia-bao,WEI Yuan-yuan,LU Ru-jian..实时三维斑点追踪成像技术评价糖尿病肾病患者左心房容积及功能改变[J].中国临床医学影像杂志,2025,36(12):869-873,5.基金项目
2023年度老年健康科研项目(LKM2023041). （LKM2023041）
