中国体外生命支持2025，Vol.23Issue(6)：490-496,7.DOI:10.13498/j.cnki.chin.j.ecls.2025.06.04
主动脉夹层患者血清脑源性神经营养因子、白介素-8水平与术后认知障碍关系
Relationship Between Serum Levels of Brain-Derived Neurotrophic Factor and Interleukin-8 and Postoperative Cognitive Dysfunction in Patients With Aortic Dissection
摘要
Abstract
Objective To explore the predictive value of serum brain-derived neurotrophic factor(BDNF)and interleu-kin-8(IL-8)levels for postoperative cognitive impairment in patients with Stanford type A aortic dissection treated with extracor-poreal circulation surgery.Methods 52 patients with Stanford type A aortic dissection treated with extracorporeal circulation surgery from January 2023 to June 2024 were selected as the study subjects.They were divided into a postoperative cognitive dysfunction(POCD)group(12 cases)and a control group(40 cases)based on whether POCD occurred.Researchers collected venous blood samples from patients before surgery(T0),10 minutes after anesthesia induction(T1),immediately at the start of surgery(T2),5 minutes after circulatory arrest at the end of surgery(T3),24 hours after surgery(T4),48 hours after surgery(T5),and 72 hours after surgery(T6)to measure serum levels of BDNF and IL-8,and perform statistical analysis.Results At time T3,T4,and T5,the BDNF levels in the POCD group were significantly lower than those in the control group,and the serum IL-8 levels were significantly higher than those in the control group at time points T3 and T4,P<0.05.The incidence of POCD in patients with low levels of BDNF was significantly higher than that in patients with high levels of BDNF,and the incidence of POCD in patients with high levels of IL-8 was significantly higher than that in patients with low levels of IL-8,P<0.05.BDNF levels were significantly positively correlated with MMSE scores(r=0.683,P<0.001),while IL-8 levels were significantly neg-atively correlated with MMSE scores(r=-0.687,P<0.001).BDNF and IL-8 have diagnostic value for POCD(AUC=0.8813,95%CI:0.779-0.982,P<0.001);AUC=0.899,95%CI:0.813-0.985,P<0.001).The decrease in BDNF levels at T3 and T4 and the increase in IL-8 levels at T4 are independent risk factors for the occurrence of POCD.Conclusion BDNF levels decrease and IL-8 levels increase in postoperative POCD patients with Stanford type A aortic dissection under extracorporeal circulation.BDNF and IL-8 have a certain predictive effect on the occurrence of POCD.关键词
体外循环/Stanford A型主动脉夹层/脑源性神经营养因子/白介素-8/术后/认知功能障碍Key words
extracorporeal circulation/Stanford type A aortic dissection/brain-derived neurotrophic factor/interleukin-8/postoperative/cognitive dysfunction引用本文复制引用
LIU Jinjiang,LEI Xiaowen,WEN Xu,ZHU Hongyu,ZHAO Jing,PANG Xiaoyi,CAO Rui..主动脉夹层患者血清脑源性神经营养因子、白介素-8水平与术后认知障碍关系[J].中国体外生命支持,2025,23(6):490-496,7.基金项目
四川省医学会科研项目(Q21025) （Q21025）
绵阳市卫健委课题(2024071) （2024071）
