中国体外生命支持2025，Vol.23Issue(6)：504-508,5.DOI:10.13498/j.cnki.chin.j.ecls.2025.06.06
儿科体外膜氧合循环支持的临床结局与影响因素:单中心52例经验
Clinical Outcomes and Risk Factors of Extracorporeal Membrane Oxygenation for Circulatory Support in Pediatric Pa-tients:a Single-Center Experience of 52 Cases
XU Wanyu 1ZHANG Wenting 1WEI Tongxia 1LIAO Jianyi 1HUANG Hongjuan 1YUAN Hongliang 1SHEN Weijia 1XU Guiying 1RONG Shuhan 1WANG Hao 1WU Songhua 1LI Xin1
作者信息
- 1. Department of Cardiothoracic Surgery,Children's Hospital of Soochow University,Suzhou Jiangsu 215025,China
- 折叠
摘要
Abstract
Objective To investigate the clinical outcomes and influencing factors of extracorporeal membrane oxygen-ation(ECMO)support in pediatric patients with circulatory failure.Methods A retrospective analysis was performed on 52 children who received ECMO support for circulatory failure at the Children's Hospital of Soochow University between Decem-ber 2017 to May 2025.Patients were divided into survival and death groups according to hospital discharge outcomes.Baseline characteristics,ECMO management strategies,and complications were compared between the two groups,and long-term fol-low-up was conducted among survivors.Results The successful weaning rate from ECMO was 69.2%(36/52),the hospital sur-vival rate was 51.9%(27/52),and the one-year survival rate was 42.3%(22/52).The proportions of patients receiving extracor-poreal cardiopulmonary resuscitation(ECPR)and renal replacement therapy were significantly higher in the death group than in the survival group(56.0%vs.14.8%,P=0.005;76.0%vs.40.7%,P=0.022).Multivariate logistic regression identified ECPR as an independent risk factor for in-hospital mortality(OR=0.163,95%CI:0.038-0.703,P=0.015),while renal replacement therapy showed a trend toward an increased risk of death(P=0.068).During follow-up,primary disease-related problems were the lead-ing cause of long-term morbidity(33.3%),followed by neurological sequelae(25.9%)and moderate exercise intolerance(7.4%).Conclusion ECPR is an independent risk factor for poor outcomes in pediatric patients supported with ECMO,whereas the need for renal replacement therapy indicates critical illness and is associated with adverse prognosis.Primary disease exerts a sig-nificant impact on long-term outcomes,underscoring the importance of targeted management and structured long-term follow-up to improve overall prognosis.关键词
体外膜氧合/小儿/循环衰竭/先天性心脏病/暴发性心肌炎/体外心肺复苏Key words
extracorporeal membrane oxygenation/pediatric/circulatory failure/congenital heart disease/fulminant myocarditis/extracorporeal cardiopulmonary resuscitation引用本文复制引用
XU Wanyu,ZHANG Wenting,WEI Tongxia,LIAO Jianyi,HUANG Hongjuan,YUAN Hongliang,SHEN Weijia,XU Guiying,RONG Shuhan,WANG Hao,WU Songhua,LI Xin..儿科体外膜氧合循环支持的临床结局与影响因素:单中心52例经验[J].中国体外生命支持,2025,23(6):504-508,5.
