中国医学科学院学报2025，Vol.47Issue(6)：947-953,7.DOI:10.3881/j.issn.1000-503X.16469
酰胺质子转移加权成像及T2 mapping成像对子宫内膜样腺癌微卫星不稳定状态的预测价值
Predicting Value of Amide Proton Transfer-Weighted Imaging and T2 Mapping for Microsatellite Instability in Endometrial Adenocarcinoma
CHENG Lianhua 1CHANG Lingyu 1YU Dexin 1WANG Qing 1JIA Jinzheng 2WANG Fang1
作者信息
- 1. Department of Radiology,Qilu Hospital of Shandong University,Jinan 250012,China
- 2. Department of Radiology,Pingdu Hospital of Traditional Chinese Medicine,Qingdao,Shandong 266700,China
- 折叠
摘要
Abstract
Objective To explore the value of amide proton transfer-weighted imaging(APTw)and T2 mapping in assessing microsatellite instability(MSI)in endometrial adenocarcinoma.Methods The patients with clinically suspected endometrial cancer were prospectively enrolled and underwent APTw and T2 mapping before operation.Two radiologists independently outlined the regions of interest and measured the quantitative parameters.The intragroup correlation coefficients were calculated to assess the agreement of MRI parameters measured by the two radiologists.The independent samples t-test and Mann-Whitney U test were conducted to compare quantitative variables between the MSI and microsatellite stability(MSS)groups.The receiver operator characteristic curve was established to evaluate the prediction performance of different parameters.The DeLong test was implemented to compare the area under the curve(AUC)between single parameters and their combina-tion.Results Twenty-one patients in the MSI group and 37 patients in the MSS group were finally enrolled in this study.The results showed excellent agreement between two radiologists in assessing MRI parameters.The MSI group had higher APTw values[(2.72±0.52)%vs.(2.08±0.39)%,P＜0.001]and lower T2 values[92.25(90.82,99.91)ms vs.101.80(96.15,112.13)ms,P＜0.001]than the MSS group.The receiver operating characteristic curve showed that the AUC of APTw and T2 values were 0.821(95%CI=0.698-0.909)and 0.793(95%CI=0.666-0.888),respectively.No significant difference in diagnostic efficacy was observed between the two sequences(P=0.692).The combination of APTw and T2 mapping yielded the high-est AUC of 0.897(95%CI=0.789-0.961),which was higher than that of APTw and T2 mapping alone(P=0.042,P=0.025,respectively).Conclusions APTw and T2 mapping are valuable in assessing the MSI of endometrial adenocarcinoma,and the combination of the two demonstrates higher diagnostic efficacy,thus provi-ding a basis for the selection of preoperative therapeutic modalities for the patients.关键词
子宫内膜样腺癌/酰胺质子转移加权成像/T2 mapping/微卫星不稳定性Key words
endometrial adenocarcinoma/amide proton transfer-weighted imaging/T2 mapping/microsatellite instability分类
医药卫生引用本文复制引用
CHENG Lianhua,CHANG Lingyu,YU Dexin,WANG Qing,JIA Jinzheng,WANG Fang..酰胺质子转移加权成像及T2 mapping成像对子宫内膜样腺癌微卫星不稳定状态的预测价值[J].中国医学科学院学报,2025,47(6):947-953,7.
