中国合理用药探索2025，Vol.22Issue(12)：68-74,7.DOI:10.3969/j.issn.2096-3327.2025.12.009
玉屏风颗粒治疗儿童反复呼吸道感染的疗效及机制研究
Study on the Efficacy and Mechanism of Yupingfeng Granules in Treating Pediatric Recurrent Respiratory Tract Infections
摘要
Abstract
Objective:To explore the clinical efficacy of Yupingfeng granules in treating pediatric patients with recurrent respiratory tract infections.Methods:A total of 126 children with recurrent respiratory tract infections admitted to a hospital between January 2020 and December 2023 were selected and assigned to Group A and Group B using simple random number table method,with 63 patients in each group.Pediatric patients in Group A received the basic treatment regimen,while those in Group B received Yupingfeng granules in addition to the treatment given in Group A.The levels of inflammatory factors[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-5(IL-5),interleukin-4(IL-4),procalcitonin(PCT)],immune function parameters[immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin A(IgA)],clinical efficacy and adverse reactions were compared between the two groups.Data mining was performed using IBM SPSS Modeler 18.0 software to analyze the factors influencing the clinical efficacy of the treatment in pediatric patients.Results:After treatment,the levels of IFN-γ,TNF-α,IL-5,IL-4 and PCT decreased in both groups,with Group B showing lower levels than Group A(P<0.05).The levels of IgM,IgG and IgA increased in both groups,with Group B showing higher levels than Group A(P<0.05).The total effective rate in Group B(95.24%)was higher than that in Group A(79.37%,P<0.05).No statistically significant difference was observed in the total incidence of adverse reactions between the two groups(P>0.05).The results of data mining indicated that the treatment method was the most significant factor influencing the clinical efficacy in pediatric patients,with an importance evaluation coefficient of 0.9679.Cluster analysis for the clinical characteristics of pediatric patients with varying treatment outcomes revealed that PCT,disease duration and group had higher peaks in the moderate response group and the special response group,and age had higher peaks in all four corresponding groups.Conclusion:Yupingfeng granules demonstrated favorable clinical efficacy in treating pediatric recurrent respiratory tract infections,effectively reducing inflammatory factor levels and improving immune function.关键词
玉屏风颗粒/治疗/儿童反复呼吸道感染/疗效/炎症因子/免疫功能Key words
Yupingfeng granules/treatment/pediatric recurrent respiratory tract infections/efficacy/inflammatory factors/immune function分类
医药卫生引用本文复制引用
YUAN Yi,LU Xiang-peng,YANG Wei-qin,DU Feng-cai,CHEN Hui-min..玉屏风颗粒治疗儿童反复呼吸道感染的疗效及机制研究[J].中国合理用药探索,2025,22(12):68-74,7.基金项目
河南省中医药科学研究专项课题(2021JDZY027) （2021JDZY027）
