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淫羊藿多糖组分介导的自组装纳米粒对淫羊藿苷增溶促渗研究

HUANG Bin YANG Yan-jun YANG Bing ZHU Mao-mao FENG Liang JIA Xiao-bin

中国中药杂志2025，Vol.50Issue(23)：6505-6514,10.

中国中药杂志2025，Vol.50Issue(23)：6505-6514,10.DOI:10.19540/j.cnki.cjcmm.20250916.302

淫羊藿多糖组分介导的自组装纳米粒对淫羊藿苷增溶促渗研究

Solubilization and permeation enhancement of icariin by Epimedium polysaccharide-mediated self-assembled nanoparticles

HUANG Bin ¹YANG Yan-jun ¹YANG Bing ¹ZHU Mao-mao ²FENG Liang ³JIA Xiao-bin⁴

作者信息

1. School of Traditional Chinese Pharmacy,Affiliated Jiangning Hospital of Chinese Medicine,China Pharmaceutical University,Nanjing 211198,China||Jiangsu Provincial Key Laboratory of Pediatric Traditional Chinese Medicine and Specialized Formulations,Jumpcan Pharmaceutical Co.,Ltd.,Taixing 225400,China
2. Nanjing Institute of Product Quality Inspection,Nanjing 210019,China
3. School of Traditional Chinese Pharmacy,Affiliated Jiangning Hospital of Chinese Medicine,China Pharmaceutical University,Nanjing 211198,China||Nanjing Jiangning District Hospital of Chinese Medicine,Nanjing 211100,China
4. School of Traditional Chinese Pharmacy,Affiliated Jiangning Hospital of Chinese Medicine,China Pharmaceutical University,Nanjing 211198,China
折叠

摘要

Abstract

In recent years,self-assembled nanostructures of TCM polysaccharides have attracted widespread attention in drug delivery systems.This study investigated the effects of two Epimedium polysaccharides,a neutral polysaccharide(EPSN)and an acidic polysaccharide(EPSA),on the loading of the active component icariin(ICA)and their influence on biopharmaceutical properties.Structural characterization revealed EPSN as a glucan and EPSA as an acidic heteropolysaccharide,both exhibiting triple-helix conformations.Dynamic light scattering(DLS),critical aggregation concentration(CAC),and electron microscopy demonstrated that the polysaccharides self-assembled into nanoparticles in aqueous solutions.Fourier transform infrared spectroscopy(FT-IR)and differential scanning calorimetry(DSC)revealed that hydrogen bonding and π-π stacking interactions occurred between the polysaccharides and ICA.Solubility testing using the saturation shake-flask method,gastrointestinal stability assays,parallel artificial membrane permeability assay(PAMPA),and single-pass intestinal perfusion(SPIP)in rats were used to evaluate and compare the effects of the two polysaccharides on ICA solubility,stability,and permeability.The results showed that both polysaccharides enhanced ICA solubility,stability,and permeability,with EPSA showing superior solubility and stability enhancement,while EPSN exhibited better permeability-promoting effects.

关键词

淫羊藿多糖/淫羊藿苷/自组装纳米粒/功能组分

Key words

Epimedium polysaccharide/icariin/self-assembled nanoparticles/functional components

引用本文复制引用

HUANG Bin,YANG Yan-jun,YANG Bing,ZHU Mao-mao,FENG Liang,JIA Xiao-bin..淫羊藿多糖组分介导的自组装纳米粒对淫羊藿苷增溶促渗研究[J].中国中药杂志,2025,50(23):6505-6514,10.

基金项目

国家自然科学基金重点项目(82230117) （82230117）

国家自然科学基金面上项目(82474093) （82474093）

江苏省卓越博士后科研基金计划项目(2022ZB317) （2022ZB317）

中国药科大学双一流建设创新团队项目(CPU2018GF07) （CPU2018GF07）

中国中药杂志

OA北大核心

ISSN：1001-5302

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