中国中药杂志2025，Vol.50Issue(23)：6515-6527,13.DOI:10.19540/j.cnki.cjcmm.20250916.303
基于多尺度调控的石菖蒲挥发油组分热稳定性提升研究
Multiscale regulation strategies for improving thermal stability of volatile oil components from Acorus tatarinowii
摘要
Abstract
Addressing the common challenge that the volatility and degradation of volatile oil components restrict pharmaceutical development,this study focuses on a cross-scale regulation strategy of"particle modification-emulsion stabilization"to enhance the stability of volatile oil components.To address the imbalance of surface hydrophilicity and hydrophobicity of the water-insoluble precipitate(WIP)from Arisaema cum Bile-Bombyx Batryticatus extract,WIP-cellulose composite functional particles were successfully prepared via hydroxypropylmethylcellulose E50-mediated solvent volatilization,increasing the contact angle to 78°.Based on this,an O/W Pickering emulsion system containing volatile oil components from Acorus tatarinowii was constructed.The emulsion process was optimized through multidimensional stability indicators,including particle size,zeta potential,emulsion stability index(ESI),and post-centrifugation cream layer height.Optimal system stability was achieved with 8 mg·mL-1 composite particles,a 55%oil phase ratio,and high-speed shearing(14 000 r·min-1,2 min).Confocal laser scanning microscopy confirmed that the WIP-cellulose composite particles formed dense adsorption layers at the oil-water interface.Thermal stability studies at 60℃demonstrated that the Pickering emulsion system provided exceptional component protection via mesoscale structural barriers.The retention rates of key components(α-asarone,β-asarone,γ-asarone,cis-methyl isoeugenol,and β-calacorene)increased compared to free volatile oil components,while maintaining stable quantitative relationships.This study provides a novel solution for enhancing the stability of volatile oil components in solid TCM preparations through the organic integration of particle interface modification,mesostructure stabilization,and macroscopic property regulation.关键词
粒子设计/Pickering乳/羚珠散/胆南星-僵蚕提取物/石菖蒲挥发油组分/固体微粒Key words
particle design/Pickering emulsion/Lingzhu powder/Arisaema Cum Bile-Bombyx Batryticatus extract/volatile oil components of Acorus tatarinowii/solid particles引用本文复制引用
WANG Zhi-chao,SHI Ya-jun,LUAN Fei,ZHANG Xiao-fei,SUN Lu,FENG Liang,ZOU Jun-bo..基于多尺度调控的石菖蒲挥发油组分热稳定性提升研究[J].中国中药杂志,2025,50(23):6515-6527,13.基金项目
国家自然科学基金面上项目(82274105) （82274105）
陕西中医药大学科技创新人才体系建设计划项目(2024-CXTD-03) （2024-CXTD-03）
芳香中药产业化关键技术青年创新团队项目(202295) （202295）
陕西省重点研发计划项目-秦创原产业创新聚集区"四链"融合项目(2024CY-JJQ36,2024CYJJO-78) （2024CY-JJQ36,2024CYJJO-78）
西安市创新联盟技术攻关集群项目(23CXLHTJSGG0004-2023) （23CXLHTJSGG0004-2023）
