中国中药杂志2025，Vol.50Issue(23)：6539-6549,11.DOI:10.19540/j.cnki.cjcmm.20250913.301
基于超分子结构的Pickering乳改善石菖蒲挥发油组分氧化稳定性研究
Improvement of oxidative stability of volatile oil components of Acorus tatarinowii based on supramolecular structure Pickering emulsion
摘要
Abstract
This study addresses the oxidative stability bottleneck of TCM preparations containing volatile oil components by innovatively constructing a Pickering emulsion system based on"protein-polysaccharide"supramolecular structures,enabling precise regulation of the oxidative stability of volatile oil components.Chitosan-mediated heterocoagulation technology was used to prepare"Saigae Tataricae Cornu-Chitosan"composite particles.Multi-dimensional characterization using Fourier transform infrared spectroscopy,scanning electron microscopy,elemental energy spectrum analysis,and contact angle measurement revealed the physicochemical basis of the composite particles as Pickering stabilizers:the contact angle increased from 53.00° to 87.67°,indicating enhanced interfacial wettability.Scanning electron microscopy and surface element analysis showed increased particle volume,with Saigae Tataricae Cornu particles adhering to the serrated surface of chitosan,while surface sulfur(S)and phosphorus(P)elements were significantly reduced,demonstrating effective compounding of Saigae Tataricae Cornu powder with chitosan.Based on this,a Pickering emulsion of volatile oil from Acorus tatarinowii Schott was successfully constructed using a high-speed shear method.Laser confocal microscopy confirmed that the composite particles formed a dense adsorption layer at the oil-water interface,with an average droplet size of(1.77±0.70)μm and a zeta potential increased to(32.50±0.50)mV,indicating an electrostatically dominated stabilization mechanism.In ozone-accelerated oxidation tests,the emulsion exhibited outstanding protective efficacy,significantly reducing the formation of peroxides and malondialdehyde in volatile oil components(P<0.05,P<0.01),while effectively slowing the oxidative degradation of key active components(α-asarone and γ-asarone)and maintaining their quantitative structure.This study presents a tripartite solution,"raw powder incorporation-interface regulation-system stabilization",establishing an ozone-resistant Pickering emulsion system and providing a distinctive TCM-based strategy for overcoming the stability challenges of solid preparations containing volatile oil components.关键词
超分子结构/Pickering乳/臭氧稳定性/挥发油组分/品质提升Key words
supramolecular structure/Pickering emulsion/ozone stability/essential oil components/quality improvement引用本文复制引用
LIN Xiao-xiao,ZOU Jun-bo,LUAN Fei,ZHANG Xiao-fei,SUN Lu,FENG Liang,SHI Ya-jun..基于超分子结构的Pickering乳改善石菖蒲挥发油组分氧化稳定性研究[J].中国中药杂志,2025,50(23):6539-6549,11.基金项目
国家自然科学基金面上项目(82274105) （82274105）
陕西中医药大学科技创新人才体系建设计划项目(2024-CXTD-03) （2024-CXTD-03）
芳香中药产业化关键技术青年创新团队项目(2022-95) （2022-95）
陕西省重点研发计划项目-秦创原产业创新聚集区"四链"融合项目(2024CY-JJQ-36,2024CY-JJQ-78) （2024CY-JJQ-36,2024CY-JJQ-78）
西安市创新联盟技术攻关集群项目(23CXLHTJSGG0004-2023) （23CXLHTJSGG0004-2023）
