首页|期刊导航|神经药理学报|逍遥散与选择性5-羟色胺再摄取抑制剂联合治疗抑郁症的研究进展

逍遥散与选择性5-羟色胺再摄取抑制剂联合治疗抑郁症的研究进展

YANG Mao-hui DAI Yun-tao QIN Xue-mei

神经药理学报2025，Vol.15Issue(6)：47-58,12.

神经药理学报2025，Vol.15Issue(6)：47-58,12.DOI:10.3969/j.issn.2095-1396.2025.06.007

逍遥散与选择性5-羟色胺再摄取抑制剂联合治疗抑郁症的研究进展

Research Progress of Xiaoyaosan Combined with Selective Serotonin Reuptake Inhibitors in the Treatment of Depression

YANG Mao-hui ¹DAI Yun-tao ²QIN Xue-mei³

作者信息

1. Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan,030006,China||Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Taiyuan,030006,China||Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
2. Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan,030006,China||Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
3. Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan,030006,China||Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Taiyuan,030006,China
折叠

摘要

Abstract

Selective serotonin reuptake inhibitors(SSRIs)have been widely used in clinical first-line treatment of depression.SSRIs exert their antidepressant effects by activating the 5-hydroxytryptamine(5-HT)receptors and regulating the release levels of 5-HT in the brain region.Whereas the chemical structures of SSRIs are different,resulting in the differences of metabolites in vivo and the adverse reactions caused by SSRIs.Adverse reactions such as gastrointestinal function,nervous system and sexual dysfunction caused by SSRIs are related to the five internal organs disorders of body's.Traditional Chinese medicine believes that the treatment of diseases should be combined with treatment,eliminating diseases without damaging the body and restoring the physiological function of patients.As a classic prescription of traditional Chinese medicine,Xiaoyaosan has the effects of soothing liver and relieving depression,invigorating spleen and nourishing blood.Xiaoyaosan combined with SSRIs individualized medication can not only improve the antidepressant effect,but also reduce the adverse reactions caused by SSRIs.Therefore,according to the individual differences of patients with depression,Xiaoyaosan combined with suitable selective serotonin reuptake inhibitors was selected to treat depression.This article reviews the pharmacology of SSRIs,the efficacy of Xiaoyaosan and individualized medication in treating depression in recent years,providing a new perspective for the treatment of depression.

关键词

逍遥散/选择性5-羟色胺再摄取抑制剂/抑郁症/增效减副/联合用药

Key words

xiaoyaosan/selective 5-hydroxytryptamine reuptake inhibitors/depression/increasing efficiency and reducing adverse reaction/drug combination

分类

医药卫生

引用本文复制引用

YANG Mao-hui,DAI Yun-tao,QIN Xue-mei..逍遥散与选择性5-羟色胺再摄取抑制剂联合治疗抑郁症的研究进展[J].神经药理学报,2025,15(6):47-58,12.

基金项目

国家自然科学基金项目(No.82074147) （No.82074147）

神经药理学报

ISSN：2095-1396

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