神经药理学报2025，Vol.15Issue(6)：59-64,6.DOI:10.3969/j.issn.2095-1396.2025.06.008
Sinomenine抗抑郁作用机制研究进展
Research Progress on Mechanism of Antidepressant Action of Sinomenine
摘要
Abstract
Depression is a complex mental health disorder,often involving abnormal emotional regulation and cognitive impairments,marked by high recurrence rates,significant functional impairment,and challenges in achieving clinical remission.Exploring novel therapeutic strategies derived from natural products holds significant clinical value in tackling issues like poor tolerance and withdrawal symptoms linked to traditional antidepressants.Sinomenine(SIN)is a benzylisoquinoline alkaloid extracted from plants like Sinomenium acutum,and its unique anti-inflammatory and immune-regulating properties offer a new approach for treating depressive disorders.Recently,there's been a lot of research on using SIN to treat depression.This article looks at how SIN works as an antidepressant by examining neurotransmitter systems,neuroinflammatory responses,neurotrophic factors,neuroplasticity,and epigenetic regulation,offering a theoretical foundation for further research and the development of new antidepressant drugs,along with insights for clinical use.关键词
sinomenine/抑郁症/神经炎症/神经可塑性/HPA轴/表观遗传Key words
sinomenine/depression/neuroinflammation/neuroplasticity/HPA axis/epigenetics分类
医药卫生引用本文复制引用
LIU Xin-yu,WANG Zhi-jian,SHEN Zhong-fei,GUO Yan-jun..Sinomenine抗抑郁作用机制研究进展[J].神经药理学报,2025,15(6):59-64,6.基金项目
浙江省基础公益研究计划项目(No.ZCLTGD24C0901) （No.ZCLTGD24C0901）
嘉兴大学校级SRT计划项目(No.8517241021) （No.8517241021）
2025年嘉兴大学国家级大学生创新训练计划(No.202510354033) （No.202510354033）
