中国医院用药评价与分析2025，Vol.25Issue(12)：1445-1448,4.DOI:10.14009/j.issn.1672-2124.2025.12.007
取消头孢菌素常规皮试的成效及安全性评价:一项基于CHPS的真实世界研究
Efficacy and Safety of Canceling the Routine Skin Test for Cephalosporin:a Real-World Study Based on China Hospital Pharmacovigilance System
摘要
Abstract
OBJECTIVE:To evaluate the efficacy and safety of canceling the routine skin test for cephalosporins in the First Affiliated Hospital of Kunming Medical University.METHODS:Based on the China Hospital Pharmacovigilance System,taking the cancellation of routine skin test for cephalosporins in the hospital as the time point,cases before the implementation of skin test scheme were set as control group(from Feb.10th to Aug.10th,2021),and cases after the implementation of skin test scheme were set as research group(from Feb.10th to Aug.10th,2022).Data of skin test and adverse drug reactions of cephalosporins were collected and analyzed.RESULTS:A total of 63 450 patients received treatment of cephalosporins were enrolled,among which 18 825 underwent skin test for cephalosporin.The skin test rate of the control group was 56.21%(16 192/28 807),with the incidence of allergic reaction was 0.11%(32/28 807),the direct medical cost of skin test was 502 790.97 RMB,the time cost of nursing was 8 096 h.The skin test rate of the research group was 7.60%(2 633/34 643),with the incidence of allergic reaction was 0.19%(65/34 643),the direct medical cost of skin test was 85 268.78 RMB,the time cost of nursing was 1 316.5 h.The skin test rate of the research group was significantly lower than that of the control group,with statistically significant differences(P<0.05).The research group saved 425 485.05 RMB in skin test costs and 6 779.5 h in nursing compared with the control group,while the difference in incidences of allergy-related adverse drug reactions between two groups was not statistically significant(P>0.05).CONCLUSIONS:After canceling the routine skin test for cephalosporin in the hospital,the skin test rate decrease significantly,which not only reduce the cost of tests,but alleviate the workload of medical staff,and do not increase the risk of allergic-related adverse drug reactions.关键词
头孢菌素/皮试/过敏/安全性/中国医院药物警戒系统Key words
Cephalosporin/Skin test/Allergy/Safety/China Hospital Pharmacovigilance System分类
医药卫生引用本文复制引用
LIU Ruming,WANG Lujie,HU Xidan,LUO Junmei,WANG Xi,ZHANG Min..取消头孢菌素常规皮试的成效及安全性评价:一项基于CHPS的真实世界研究[J].中国医院用药评价与分析,2025,25(12):1445-1448,4.基金项目
云南省卫生健康委员会医学学科带头人培养计划(No.D-2024010) （No.D-2024010）
