中国中药杂志2025，Vol.50Issue(23)：6583-6597,15.DOI:10.19540/j.cnki.cjcmm.20250811.602
中药及活性成分干预动脉粥样硬化的关键途径:血管平滑肌细胞增殖、迁移与表型转化
Critical pathways of traditional Chinese medicine and active ingredients for intervention in atherosclerosis:proliferation,migration,and phenotypic transformation of vascular smooth muscle cells
摘要
Abstract
Atherosclerosis,a metabolic disease characterized by the formation of plaques consisting of a combination of cholesterol,calcium,fibrin,and other impurities in blood vessels,is a key risk factor for the development of a variety of cardiovascular and cerebrovascular diseases and a global health problem that needs to be addressed urgently.Vascular smooth muscle cells(VSMCs)are the main cell type in atherosclerotic plaques,and many studies have confirmed that the proliferation,migration,and phenotypic transformation of VSMCs are important driving factors for the development of atherosclerosis.VSMCs have a high degree of plasticity,and in the physiological state,VSMCs are responsible for maintaining vasoconstriction and vasodilation and supporting the normal physiological structure of the blood vessels.In case of tissue injury,abnormal lipid metabolism,and abnormal infiltration of inflammation,VSMCs can be de-differentiated into the synthetic type and possess abnormal proliferation and migration capabilities,which will lead to luminal stenosis,plaque accumulation and even rupture.The multi-target and multi-pathway holistic treatment of traditional Chinese medicine(TCM)is consistent with the complexity of this pathological process.Therefore,the intervention of TCM targeting VSMCs may be a new breakthrough.Based on the existing evidence,this study systematically reviewed the research progress of TCM targeting VSMCs proliferation,migration,and phenotypic transformation to intervene in atherosclerosis,with a view to providing evidence support for the clinical diagnosis and treatment of atherosclerosis with TCM and the exploration of the biological basis of atherosclerosis.关键词
中药/活性成分/动脉粥样硬化/血管平滑肌细胞/表型转化/增殖/迁移Key words
traditional Chinese medicine/active ingredients/atherosclerosis/vascular smooth muscle cells/phenotypic transforma-tion/proliferation/migration引用本文复制引用
LI Ji-xin,ZHOU Rui-ling,HUANG Hong-bo,DENG Yan-ping,WANG Zi-rui,LIU Sheng-jing,NIU Ze-long,WANG Wen-ru,WANG Pei-li..中药及活性成分干预动脉粥样硬化的关键途径:血管平滑肌细胞增殖、迁移与表型转化[J].中国中药杂志,2025,50(23):6583-6597,15.基金项目
国家自然科学基金项目(82474312) （82474312）
